{"id":"W2004228506","doi":"10.2174/156652308783688491","title":"Gemini Surfactants: A New Family of Building Blocks for Non-Viral Gene Delivery Systems","year":2008,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Transfection; Gene delivery; In vivo; Pulmonary surfactant; Lamellar structure; Gene; Genetic enhancement; In vitro; DNA; Chemistry; Cell biology; Computational biology; Biophysics; Biology; Biochemistry; Genetics; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001711523,0.0007221228,0.001579653,0.0001690361,0.00009454275,0.00003640552,0.000807014,0.0005289168,0.000007498996],"category_scores_gemma":[0.00002049577,0.0006168038,0.00109357,0.0001547138,0.00008311698,0.000007175054,0.0001360116,0.0002210822,0.000009419685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005045136,"about_ca_system_score_gemma":0.0009181501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004656346,"about_ca_topic_score_gemma":0.000001225411,"domain_scores_codex":[0.9972946,0.00009735973,0.000998633,0.000835873,0.0002456996,0.000527846],"domain_scores_gemma":[0.9980246,0.00004384628,0.0006852316,0.0008268538,0.000248941,0.0001705245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001425019,0.0001375634,0.00000926178,0.001554001,0.0007255483,0.000003489195,0.00003923548,0.00002768008,0.08439481,0.000002080498,0.01809779,0.894866],"study_design_scores_gemma":[0.0008842759,0.0007263266,0.000003276036,0.00235547,0.0001870712,0.00005845702,0.00001076061,0.00003099644,0.02237245,0.000005492882,0.9726673,0.0006981667],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05354793,0.9402552,0.002402928,0.000001826077,0.001916892,0.001357951,0.0004772792,0.0000162822,0.00002367171],"genre_scores_gemma":[0.001176848,0.9950183,0.0004799631,0.00002635943,0.001638495,0.0001730222,0.001002056,0.0001121722,0.0003727903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9545695,"threshold_uncertainty_score":0.9996283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07393107688159231,"score_gpt":0.3441495735148705,"score_spread":0.2702184966332781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}