{"id":"W2004228506","doi":"10.2174/156652308783688491","title":"Gemini Surfactants: A New Family of Building Blocks for Non-Viral Gene Delivery Systems","year":2008,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Transfection; Gene delivery; In vivo; Pulmonary surfactant; Lamellar structure; Gene; Genetic enhancement; In vitro; DNA; Chemistry; Cell biology; Computational biology; Biophysics; Biology; Biochemistry; Genetics; Crystallography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003590307,0.0008252913,0.0008341984,0.00161114,0.0002438014,0.0005951895,0.0006494063,0.000754717,0.0009068772],"category_scores_gemma":[0.0002080645,0.0002994105,0.0002676966,0.001160367,0.0003291505,0.00104491,0.0004637511,0.001325544,0.001515544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004897488,"about_ca_system_score_gemma":0.0003821527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004061261,"about_ca_topic_score_gemma":0.0006661285,"domain_scores_codex":[0.9998597,0.00002092612,0.00001537817,0.00002330069,0.00006698197,0.00001371579],"domain_scores_gemma":[0.9999208,0.00002310356,0.00002083758,0.000004514762,0.00001846625,0.00001223113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001044864,0.0001229129,0.0001961402,0.007681213,0.00008889183,0.000656097,0.0001853219,0.001252549,0.1895133,0.01282651,0.007730351,0.7796423],"study_design_scores_gemma":[0.00003124096,0.0002392172,0.0004376806,0.000424167,0.00005982718,0.00194275,0.00003353284,0.0004756481,0.05449282,0.001767881,0.9400611,0.00003403603],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00386374,0.9863172,0.005400532,0.00027073,0.0002292759,0.00003685531,0.00004851039,0.0001075356,0.00372564],"genre_scores_gemma":[0.01426333,0.9724476,0.007581475,0.0002448823,0.0001454878,0.00007963656,0.000162198,0.00001990766,0.005055497],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00161114,"threshold_uncertainty_score":0.003553331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07393107688159231,"score_gpt":0.3441495735148705,"score_spread":0.2702184966332781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}