{"id":"W2004256856","doi":"10.1007/s00439-011-1007-8","title":"Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation","year":2011,"lang":"en","type":"article","venue":"Human Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Pacific Centre for Reproductive Medicine; University of British Columbia","funders":"National Institute of Mental Health; National Institutes of Health; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Biology; DNA methylation; X-inactivation; Methylation; CpG site; Promoter; Epigenetics; Gene; Genetics; Differentially methylated regions; X chromosome; Intron; Regulation of gene expression; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077962,0.0001170923,0.0001874218,0.000399116,0.00008913488,0.0001726711,0.00008567717,0.0001384743,0.0010374],"category_scores_gemma":[0.0006089177,0.00009180101,0.0001597077,0.0002882267,0.00007613057,0.00006332677,0.000148867,0.0001850513,0.0002634608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009200925,"about_ca_system_score_gemma":0.00006412271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008467642,"about_ca_topic_score_gemma":0.001158335,"domain_scores_codex":[0.9998477,0.00002904158,0.00001160013,0.00005669896,0.00003551519,0.0000194997],"domain_scores_gemma":[0.9997688,0.000115551,0.00005496916,0.00001477297,0.00002914388,0.00001676105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004992865,0.00002345653,0.3885482,0.00008777257,0.0001802148,0.0001125475,0.0001308831,0.0007011665,0.5920928,0.0001009482,0.0002082488,0.01731453],"study_design_scores_gemma":[0.000005789954,0.0001156672,0.9567154,0.000003734698,0.00004974324,0.0003595939,0.00003296201,0.001161231,0.04072127,0.00007562237,0.0007549652,0.000004030711],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960936,0.0007995585,0.001609025,0.0000377723,0.000002498112,0.000006915517,0.0008293649,0.00002486202,0.0005964404],"genre_scores_gemma":[0.9976916,0.0002824482,0.0006336284,0.00002449875,0.000003690464,0.000009613659,0.0009540411,0.000006058785,0.0003944343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010374,"threshold_uncertainty_score":0.003470421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0454337516586398,"score_gpt":0.2852886149206491,"score_spread":0.2398548632620093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}