{"id":"W2004262894","doi":"10.1159/000338153","title":"Transthyretin Aggregates Induce Production of Reactive Nitrogen Species","year":2012,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Reactive nitrogen species; Cell culture; Neurodegeneration; Nitrite; Molecular biology; Biochemistry; Internal medicine; Reactive oxygen species; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005721037,0.0002561827,0.0002364784,0.00006085543,0.00009643709,0.00001340186,0.0001343476,0.00006952293,0.00003619939],"category_scores_gemma":[0.0003122904,0.0002249955,0.000178397,0.0001315546,0.000185158,0.00002439173,0.00005304496,0.00006536897,0.00001212836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002293567,"about_ca_system_score_gemma":0.00006002539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001223788,"about_ca_topic_score_gemma":0.000007562686,"domain_scores_codex":[0.9987049,0.0001855908,0.0002235094,0.0004011902,0.0001848568,0.0002999897],"domain_scores_gemma":[0.9991595,0.00003239101,0.0001641846,0.0003503019,0.0001460187,0.0001476042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316948,0.0005902454,0.3489177,0.00001749175,0.000143281,0.000001437445,0.0002129022,0.00002740678,0.6468682,0.0001819093,0.002030688,0.000877102],"study_design_scores_gemma":[0.0002680433,0.0001806402,0.1637023,0.00001067998,0.0001184261,0.000004423906,0.0001754596,7.928302e-7,0.8327958,0.00002656476,0.002542888,0.000173993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936143,0.004723345,0.00003069947,0.0003197961,0.0003410825,0.0003491615,0.0001895017,0.00002403826,0.0004081234],"genre_scores_gemma":[0.9975699,0.000658227,0.0001660869,0.0001806712,0.0005490101,0.0001364951,0.000276645,0.00003679623,0.0004261294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1859276,"threshold_uncertainty_score":0.9175049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167672173117462,"score_gpt":0.2581860477524994,"score_spread":0.2414188304407532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}