{"id":"W2004265660","doi":"10.1016/j.ab.2013.07.040","title":"Quantitative affinity electrophoresis of RNA–small molecule interactions by cross-linking the ligand to acrylamide","year":2013,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Ontario Centres of Excellence","keywords":"RNA; Chemistry; Ligand (biochemistry); Gel electrophoresis; Aminoglycoside; Binding site; Small molecule; Biochemistry; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007396798,0.001223852,0.0005686908,0.0009769845,0.0008414424,0.001142484,0.00131484,0.0006194814,0.005211417],"category_scores_gemma":[0.0009620856,0.0007311929,0.0004787653,0.0008060993,0.0005812218,0.0007615333,0.0004598136,0.002512971,0.003013816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00119996,"about_ca_system_score_gemma":0.0009823771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002082384,"about_ca_topic_score_gemma":0.004246113,"domain_scores_codex":[0.9991419,0.0001630066,0.00004945252,0.0002058887,0.0002440915,0.0001956355],"domain_scores_gemma":[0.9986003,0.0006402751,0.0001522187,0.0001416187,0.0002539623,0.0002115934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007491205,0.00003895399,0.0000485587,0.00004428401,0.000006883851,0.00001751913,0.00003967996,0.00006217153,0.9977255,0.0003917306,0.000121437,0.001428301],"study_design_scores_gemma":[0.00001124546,0.00007320142,0.0008356521,0.000008582768,0.00001227487,0.00006162749,0.000022172,0.001956565,0.9953743,0.0001733475,0.001461508,0.000009701742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5294671,0.003849024,0.4481922,0.001065229,0.0002366308,0.0003222963,0.0007560726,0.003984907,0.01212648],"genre_scores_gemma":[0.7522701,0.004072728,0.1957043,0.0006501575,0.0001332891,0.0007666343,0.003064798,0.0009777026,0.04236037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005211417,"threshold_uncertainty_score":0.01743394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363901261382201,"score_gpt":0.2837223171382698,"score_spread":0.2700833045244478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}