{"id":"W2004270155","doi":"10.1135/cccc20061063","title":"Synthesis and Biological Evaluation of Some 4'-C-(Hydroxymethyl)-α- and -β-D-Arabinofuranosyl Pyrimidine and Adenine Nucleosides","year":2006,"lang":"en","type":"article","venue":"Collection of Czechoslovak Chemical Communications","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Deoxycytidine kinase; Pyrimidine; Nucleoside; Thymidine kinase; Purine; Thymidine; Hydroxymethyl; Biochemistry; Chemistry; Kinase; Nucleoside analogue; Adenosine kinase; Cytotoxicity; Purine metabolism; Enzyme; Stereochemistry; Adenosine deaminase; Deoxycytidine; Biology; DNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693352,0.0003647415,0.0003397467,0.0002945497,0.0001931154,0.0001495308,0.0002462592,0.0001886931,0.00117313],"category_scores_gemma":[0.0001784397,0.0001234103,0.0002413674,0.0002294728,0.0001334661,0.0001655009,0.0001277312,0.0002585704,0.0002089377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214163,"about_ca_system_score_gemma":0.000290952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005737,"about_ca_topic_score_gemma":0.0009862346,"domain_scores_codex":[0.9999013,0.00002658753,0.0000116538,0.00001538041,0.0000254848,0.00001949888],"domain_scores_gemma":[0.9999057,0.00001397105,0.00002070254,0.00001353284,0.0000210444,0.00002498343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000967093,0.00005392764,0.0001200928,0.0001542042,0.000008201097,0.0001033017,0.00002688544,0.0005252447,0.9923184,0.0001642719,0.00003612828,0.006392625],"study_design_scores_gemma":[0.00002343046,0.00112542,0.001038513,0.000009841789,0.00002795983,0.0002466203,0.00001371274,0.0002505205,0.9917113,0.00003705658,0.005508014,0.000007599635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702903,0.01540105,0.007287656,0.00008907501,0.0000807139,0.0002856153,0.0008325709,0.00006185463,0.005671214],"genre_scores_gemma":[0.9746982,0.007596522,0.01362449,0.00006702931,0.00004184487,0.0001469713,0.00087476,0.00001519709,0.002934915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117313,"threshold_uncertainty_score":0.003924549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04698025935926908,"score_gpt":0.3000911184388823,"score_spread":0.2531108590796132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}