{"id":"W2004274140","doi":"10.2217/whe.12.2","title":"<i>BRCA1</i>Haploinsufficiency: Consequences for Breast Cancer","year":2012,"lang":"en","type":"letter","venue":"Women s Health","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"","keywords":"Haploinsufficiency; Loss of heterozygosity; Genome instability; Genetics; Biology; Allele; Mutation; Germline mutation; Epigenetics; Somatic cell; Phenotype; Cancer research; Gene; Mutant; Molecular biology; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004545696,0.0003497131,0.0004045249,0.00008948056,0.0002345318,0.00003796489,0.0004101431,0.0006111841,0.0002227727],"category_scores_gemma":[0.00002085055,0.0003380528,0.0001262994,0.0001319343,0.0002670756,0.000004291752,0.00007622226,0.000450263,0.0000257491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008316607,"about_ca_system_score_gemma":0.003987188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001813524,"about_ca_topic_score_gemma":0.00008490586,"domain_scores_codex":[0.9974314,0.0001086973,0.000413256,0.0006645136,0.0002554974,0.001126643],"domain_scores_gemma":[0.9986809,0.00003137171,0.0003674788,0.0005694885,0.0001766784,0.0001741195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000339085,0.00003239282,0.0001227719,0.0003864925,0.000101044,0.00000171514,0.0003278346,0.00001646965,0.00111316,0.00001940198,0.9908357,0.007009088],"study_design_scores_gemma":[0.0003532984,0.0002275642,0.0001639209,0.00004579949,0.00001742123,0.00005662586,0.00009739596,0.000003729906,0.0005156467,0.0001130961,0.9980267,0.0003788265],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006343323,0.01453535,0.0009093968,0.9658279,0.003049531,0.001449137,0.007129123,0.00006006222,0.0006961445],"genre_scores_gemma":[0.02888125,0.002043668,0.0011356,0.9465155,0.01284427,0.002165264,0.001204669,0.0001444304,0.005065349],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02253793,"threshold_uncertainty_score":0.9999071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248057728822727,"score_gpt":0.313930556690426,"score_spread":0.2914499794021987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}