{"id":"W2004274140","doi":"10.2217/whe.12.2","title":"<i>BRCA1</i>Haploinsufficiency: Consequences for Breast Cancer","year":2012,"lang":"en","type":"letter","venue":"Women s Health","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"","keywords":"Haploinsufficiency; Loss of heterozygosity; Genome instability; Genetics; Biology; Allele; Mutation; Germline mutation; Epigenetics; Somatic cell; Phenotype; Cancer research; Gene; Mutant; Molecular biology; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005646029,0.0006934633,0.000735118,0.0003471113,0.001163681,0.0008673358,0.0007537252,0.01170179,0.003835548],"category_scores_gemma":[0.003903874,0.0003143978,0.0006275641,0.0002474777,0.000935839,0.0006647751,0.0002836047,0.005664107,0.002332956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001789323,"about_ca_system_score_gemma":0.0005018081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001577782,"about_ca_topic_score_gemma":0.002248575,"domain_scores_codex":[0.999558,0.0001305309,0.00004525159,0.00008056052,0.0001039553,0.00008173058],"domain_scores_gemma":[0.9991523,0.0004526218,0.00006559878,0.00004732267,0.0001378938,0.0001441375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008001389,0.0002676143,0.00844676,0.0002131865,0.00005962708,0.2297437,0.0003174462,0.0002820469,0.007722576,0.004719438,0.7029428,0.04448464],"study_design_scores_gemma":[0.0005021951,0.0009576716,0.02103586,0.0003265797,0.0001937991,0.2884267,0.0005420061,0.003347796,0.0101214,0.01267619,0.6617218,0.0001479504],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02442788,0.004104182,0.0004421111,0.9336516,0.02172801,0.00006351581,0.0001944283,0.0001972717,0.01519104],"genre_scores_gemma":[0.2580975,0.009048785,0.001457049,0.5901386,0.08414926,0.0001327455,0.000269571,0.0001434349,0.05656314],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01170179,"threshold_uncertainty_score":0.01298249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248057728822727,"score_gpt":0.313930556690426,"score_spread":0.2914499794021987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}