{"id":"W2004321823","doi":"10.1002/ana.22446","title":"Gene therapy for pain: Results of a phase I clinical trial","year":2011,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Medicine; Cancer pain; Adverse effect; Placebo; Ketamine; McGill Pain Questionnaire; Radicular pain; Clinical trial; Opioid; Anesthesia; Internal medicine; Cancer; Surgery; Visual analogue scale; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001274085,0.00008044067,0.0004108297,0.00005453507,0.00001248408,4.730354e-7,0.00006751486,0.000123495,0.00002823215],"category_scores_gemma":[0.0006763499,0.00005997039,0.0002191233,0.00004318053,0.0000736807,0.00001330434,0.00001134556,0.00006870175,0.000002112244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":4.517844e-7,"about_ca_system_score_gemma":0.00004223953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002088217,"about_ca_topic_score_gemma":0.000001358508,"domain_scores_codex":[0.9988112,0.0002370511,0.0005219979,0.0001989617,0.00007399597,0.0001567235],"domain_scores_gemma":[0.9988614,0.0004361283,0.0002366708,0.0002653523,0.0001296067,0.00007084469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8555878,0.008334999,0.001000474,0.00002193483,0.0004050994,0.0001052048,0.0001882085,1.004871e-7,0.006370524,0.0003259335,0.005313063,0.1223466],"study_design_scores_gemma":[0.4955864,0.3227384,0.009230111,0.00001531209,0.0001288666,0.00002518171,0.000008857749,0.0001859997,0.1414561,0.007309312,0.02318726,0.00012814],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963105,0.0001364115,0.0002909742,0.001954648,0.0002173224,0.0006994944,0.0000469949,0.0000112183,0.000332447],"genre_scores_gemma":[0.9920365,0.0004582617,0.001088569,0.006144335,0.0001518835,0.00003191267,0.00002104448,0.00001170913,0.00005577318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3600014,"threshold_uncertainty_score":0.2445522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4590816886586612,"score_gpt":0.4848119857603723,"score_spread":0.0257302971017111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}