{"id":"W2004340067","doi":"10.1074/jbc.m001938200","title":"Translational Control of the Antiapoptotic Function of Ras","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"Cycloheximide; EIF4E; Cell biology; Translation (biology); Apoptosis; Ectopic expression; Protein biosynthesis; Repressor; Biology; Signal transduction; Chemistry; Molecular biology; Cell culture; Messenger RNA; Gene expression; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266297,0.00009041549,0.000198351,0.000007617,0.00002340276,0.000003000386,0.0002262739,0.0001910494,0.0005999024],"category_scores_gemma":[0.00008604617,0.00005460663,0.0002526019,0.00006341709,0.0001796093,0.00000266502,0.00001163602,0.0001403921,6.639687e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007596209,"about_ca_system_score_gemma":0.00008416922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.888701e-7,"about_ca_topic_score_gemma":1.175432e-7,"domain_scores_codex":[0.9991661,0.00004684578,0.0004151098,0.0001050466,0.0001649944,0.0001018569],"domain_scores_gemma":[0.9993152,0.00003491397,0.000321413,0.0001399431,0.0001483487,0.00004015037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005216411,0.00007193076,0.008878364,0.00002008447,0.00008618188,6.241173e-7,0.000004763472,0.0005945697,0.9878213,0.000004169227,0.0001874281,0.001808883],"study_design_scores_gemma":[0.0008917727,0.0002922988,0.01743061,0.00003543497,0.00004423351,0.000039618,0.000008979702,0.00002238619,0.9775606,0.000165592,0.003438798,0.00006967555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967023,0.001362458,0.0008660262,0.0001356033,0.00008692462,0.00004075428,0.00002506861,0.000001556555,0.000779336],"genre_scores_gemma":[0.9992479,0.0001172651,0.0001178477,0.00009064841,0.0002999683,8.88744e-7,0.000006404477,0.000004889856,0.0001141987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01026076,"threshold_uncertainty_score":0.6568511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151177751980317,"score_gpt":0.2337382260609143,"score_spread":0.2222264485411111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}