{"id":"W2004345196","doi":"10.1021/op200186d","title":"Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245","year":2011,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Tetrazole; Stereochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00210903,0.0004116812,0.000675849,0.0004487623,0.0002926426,0.00004212585,0.001078538,0.000289446,0.004560969],"category_scores_gemma":[0.006117086,0.0003750381,0.00008448141,0.0008910511,0.0004945482,0.0003613535,0.0006622562,0.0006874742,0.0001974071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004603345,"about_ca_system_score_gemma":0.004714176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001553384,"about_ca_topic_score_gemma":0.00002758639,"domain_scores_codex":[0.9944244,0.0001388455,0.001332173,0.0007690399,0.002330531,0.001004996],"domain_scores_gemma":[0.9962847,0.0009971232,0.0004588236,0.0006859853,0.001194886,0.0003785348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000495862,0.001606951,0.002938126,0.002282044,0.0004895677,0.0000522761,0.02160665,1.370732e-7,0.9187317,0.0001374789,0.0002991684,0.05136007],"study_design_scores_gemma":[0.0003791429,0.00002858952,0.00505132,0.0007631547,0.00002147221,0.00001559659,0.007105959,0.000004610694,0.9841474,0.000155828,0.001918982,0.000407934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877182,0.0001722656,0.0001730576,0.0001313059,0.00004468847,0.0003071112,0.00001056343,0.00009918301,0.01134365],"genre_scores_gemma":[0.9211673,0.00005224858,0.07805811,0.000009362629,0.00004394386,0.0002668391,0.000008644782,0.00008637808,0.0003071908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07788505,"threshold_uncertainty_score":0.9998702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1024653224323612,"score_gpt":0.3576989075953255,"score_spread":0.2552335851629643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}