{"id":"W2004395588","doi":"10.1016/s0161-5890(00)00046-8","title":"The extracellular domain of CD4 regulates the initiation of T cell activation","year":2000,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; McGill University; Montreal Clinical Research Institute","funders":"Medical Research Council","keywords":"Extracellular; Cell biology; T-cell receptor; Transfection; T cell; MHC class II; Intracellular; Jurkat cells; Biology; MHC class I; clone (Java method); Major histocompatibility complex; Chemistry; Cell culture; Biochemistry; Antigen; Immunology; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004603971,0.0002275619,0.0003506445,0.00009355025,0.0003520545,0.000009892649,0.0006508822,0.0004374938,0.0008162176],"category_scores_gemma":[0.00005701018,0.0001469046,0.0001881582,0.0002671998,0.001277779,0.00006660102,0.0001002535,0.000430346,0.0002065366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002777887,"about_ca_system_score_gemma":0.00007118285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001166654,"about_ca_topic_score_gemma":0.000007062678,"domain_scores_codex":[0.9977488,0.0008290735,0.0006504856,0.000277728,0.00006227436,0.0004316582],"domain_scores_gemma":[0.9982338,0.0004012106,0.0004047898,0.0008187722,0.0001327487,0.000008698235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003571098,0.0001720459,0.00004741799,0.00001104201,0.0002626784,0.000003301831,0.000519979,0.00003118025,0.9841772,0.006105069,0.0002204472,0.008092509],"study_design_scores_gemma":[0.001149448,0.000309749,0.000766232,0.00001721654,0.00004979294,0.00004569316,0.0004340383,0.00000363701,0.9522425,0.002966333,0.04187642,0.000138958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767507,0.01802208,0.000350622,0.000872037,0.0003312616,0.0003458216,0.000008191085,0.00003600057,0.003283225],"genre_scores_gemma":[0.9957275,0.00070053,0.00008637019,0.00008102143,0.00001115731,0.00003524563,0.00008625018,0.00002469321,0.003247166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04165597,"threshold_uncertainty_score":0.893701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005459895125404299,"score_gpt":0.1940220603898343,"score_spread":0.18856216526443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}