{"id":"W2004472445","doi":"10.1042/bsr20120095","title":"Promoter analysis of the DHCR24 (3β-hydroxysterol Δ24-reductase) gene: characterization of SREBP (sterol-regulatoryelement-binding protein)-mediated activation","year":2012,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerio de Ciencia y Tecnología; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Yonsei University; York University; Instituto de Salud Carlos III; Comunidad de Madrid","keywords":"Biology; Chromatin immunoprecipitation; Sterol regulatory element-binding protein; Transcription factor; Sterol; Gene expression; Regulation of gene expression; Promoter; Gene; Transcription (linguistics); Cell biology; Biochemistry; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00090225,0.0001745599,0.0004544411,0.0004048885,0.00008896708,0.0000180991,0.0001235608,0.0001032988,0.0000578793],"category_scores_gemma":[0.0001890862,0.0001161769,0.0001980131,0.001663034,0.0001806186,0.0004362276,0.0000793587,0.00009890489,0.000001671787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006361587,"about_ca_system_score_gemma":0.000130543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002786753,"about_ca_topic_score_gemma":0.000001509615,"domain_scores_codex":[0.9976544,0.00008160775,0.0008070748,0.0003349246,0.0007862546,0.0003356847],"domain_scores_gemma":[0.9978164,0.0000121553,0.001163558,0.000681449,0.0001795143,0.0001468837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000156703,0.0001860889,0.1604666,0.00005780145,0.0001049882,0.000001256383,0.0005227023,0.000001152309,0.8376549,0.000005639209,0.000004339461,0.0009788544],"study_design_scores_gemma":[0.000143123,0.0000282381,0.4526525,0.00007622735,0.0003135331,0.000021104,0.00002934017,0.00009367074,0.5461403,7.554452e-7,0.000438969,0.0000622634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979881,0.00001884413,0.0001447057,0.0002507113,0.0005320238,0.0009680754,0.0000238341,0.00002621797,0.00004750878],"genre_scores_gemma":[0.9991433,0.00000342061,0.0001215081,0.00008669709,0.0001607461,0.00003717679,0.000115463,0.00001421197,0.0003174893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2921858,"threshold_uncertainty_score":0.4737557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508388540315096,"score_gpt":0.2521625901853253,"score_spread":0.2370787047821743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}