{"id":"W2004472445","doi":"10.1042/bsr20120095","title":"Promoter analysis of the DHCR24 (3β-hydroxysterol Δ24-reductase) gene: characterization of SREBP (sterol-regulatoryelement-binding protein)-mediated activation","year":2012,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerio de Ciencia y Tecnología; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Yonsei University; York University; Instituto de Salud Carlos III; Comunidad de Madrid","keywords":"Biology; Chromatin immunoprecipitation; Sterol regulatory element-binding protein; Transcription factor; Sterol; Gene expression; Regulation of gene expression; Promoter; Gene; Transcription (linguistics); Cell biology; Biochemistry; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002022488,0.0005287986,0.000593138,0.0005953724,0.0002199935,0.0003253623,0.0004649553,0.0003022305,0.003376166],"category_scores_gemma":[0.0002193504,0.0002700311,0.001060598,0.0004885799,0.0003823032,0.0001398876,0.0002638104,0.0007817355,0.002346296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000499294,"about_ca_system_score_gemma":0.0004425318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002320773,"about_ca_topic_score_gemma":0.002962281,"domain_scores_codex":[0.9997112,0.00002528282,0.00001886915,0.000106498,0.00008074054,0.00005742368],"domain_scores_gemma":[0.9997608,0.0000648547,0.00004709366,0.00002240797,0.00004609241,0.00005871978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007083338,0.00002236818,0.0001546559,0.0000585387,0.000004440376,0.00004194066,0.00002138443,0.00005452469,0.9987414,0.00004466264,0.00002531111,0.0007599171],"study_design_scores_gemma":[0.00002267723,0.0001450935,0.007597208,0.00001832445,0.00003387939,0.0003354114,0.00006771811,0.001080074,0.9857891,0.00005309616,0.004843589,0.00001384651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156184,0.005633227,0.05133154,0.0005078627,0.0001585626,0.0005103354,0.0217188,0.0007096226,0.003811601],"genre_scores_gemma":[0.8887967,0.003039542,0.05545453,0.0003370492,0.00006489564,0.0004363568,0.03709031,0.0004299745,0.01435078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003376166,"threshold_uncertainty_score":0.01129436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508388540315096,"score_gpt":0.2521625901853253,"score_spread":0.2370787047821743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}