{"id":"W2004500070","doi":"10.1002/ijc.24761","title":"Sp1 coordinately regulates <i>de novo</i> lipogenesis and proliferation in cancer cells","year":2009,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Promoter; Cell growth; Biology; Sp1 transcription factor; Lipogenesis; Transcription factor; Cancer cell; CDC25A; Cancer research; Sterol regulatory element-binding protein; Gene expression; Cell biology; Molecular biology; Gene; Cell cycle; Cancer; Biochemistry; Genetics; Cell cycle checkpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686015,0.0004315828,0.0004394913,0.0003775071,0.0003592017,0.0005284502,0.0002290682,0.0002604475,0.001470235],"category_scores_gemma":[0.0001753039,0.0002126421,0.0004422392,0.0002949369,0.0002086599,0.0001948594,0.0004921959,0.0007497136,0.0009444751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003826972,"about_ca_system_score_gemma":0.0002338393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000631488,"about_ca_topic_score_gemma":0.0009296617,"domain_scores_codex":[0.9997587,0.00003403513,0.00001696259,0.00006625214,0.00007030222,0.00005379936],"domain_scores_gemma":[0.9998083,0.00002632937,0.00004094549,0.0000213822,0.00005695528,0.00004611773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001861701,0.000027885,0.001333337,0.0001266649,0.00001745303,0.0001528558,0.00004788011,0.0001456892,0.9895902,0.0002747181,0.0006523756,0.007444741],"study_design_scores_gemma":[0.00005933406,0.0003469145,0.03959572,0.0000352489,0.00008310605,0.001165187,0.0001450911,0.003293706,0.9283662,0.0005380316,0.0263485,0.00002304059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9409628,0.02932945,0.01404625,0.0007946997,0.0003940041,0.0001304391,0.002052555,0.0008500642,0.0114396],"genre_scores_gemma":[0.9743947,0.007773675,0.005925593,0.0002713092,0.0001306017,0.0001237213,0.002588981,0.0001148329,0.008676737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470235,"threshold_uncertainty_score":0.004918456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007681988935120538,"score_gpt":0.2909608046077372,"score_spread":0.2832788156726166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}