{"id":"W2004500070","doi":"10.1002/ijc.24761","title":"Sp1 coordinately regulates <i>de novo</i> lipogenesis and proliferation in cancer cells","year":2009,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Promoter; Cell growth; Biology; Sp1 transcription factor; Lipogenesis; Transcription factor; Cancer cell; CDC25A; Cancer research; Sterol regulatory element-binding protein; Gene expression; Cell biology; Molecular biology; Gene; Cell cycle; Cancer; Biochemistry; Genetics; Cell cycle checkpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553433,0.00009140997,0.0001324358,0.00008721553,0.0000174983,0.00003659181,0.0001511823,0.00007135497,0.00003310333],"category_scores_gemma":[0.0000210479,0.00008350622,0.00005887633,0.00004809555,0.00002805579,0.00001609268,0.00001879903,0.00007893612,3.915838e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007239947,"about_ca_system_score_gemma":0.0002241806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009644025,"about_ca_topic_score_gemma":0.0003172313,"domain_scores_codex":[0.9992859,0.00002462,0.0002585959,0.0001231553,0.0001839174,0.0001237912],"domain_scores_gemma":[0.9994155,0.000006177441,0.000171004,0.00005815604,0.0002888944,0.00006028579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004675222,0.00006083013,0.009382205,0.000005580386,0.00009347273,0.000001775147,0.0001257184,0.001323264,0.9239941,0.00007051944,0.008055073,0.05641999],"study_design_scores_gemma":[0.001847486,0.0001569471,0.05713909,0.00009992163,0.00004125504,0.00008846211,0.00002998306,0.00008797641,0.57636,0.0003466264,0.3636323,0.0001699239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796602,0.01306945,0.0001810805,0.002247367,0.004604021,0.00006552431,0.00002278365,0.000002257786,0.0001473867],"genre_scores_gemma":[0.9743267,0.01334552,0.0002152034,0.001214125,0.01052693,0.000007895329,0.000004168387,0.000008983925,0.0003504321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3555773,"threshold_uncertainty_score":0.3405285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007681988935120538,"score_gpt":0.2909608046077372,"score_spread":0.2832788156726166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}