{"id":"W2004507031","doi":"10.1182/blood-2013-03-489468","title":"PPARα and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Gilead Sciences; University of Toronto; Leukemia and Lymphoma Society; GlaxoSmithKline","keywords":"Chronic lymphocytic leukemia; Beta oxidation; Endocrinology; Internal medicine; Fatty acid; Biology; Glucocorticoid; Chemistry; Leukemia; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861159,0.000196405,0.000243761,0.0002825231,0.0002040628,0.0003377593,0.0001493929,0.0002820255,0.001274582],"category_scores_gemma":[0.0001818311,0.0001287542,0.0001640682,0.0002676341,0.0002854518,0.0001659272,0.0002483598,0.0003909334,0.0003122691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004047743,"about_ca_system_score_gemma":0.0001712938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009071239,"about_ca_topic_score_gemma":0.00106765,"domain_scores_codex":[0.9998862,0.00003052733,0.0000111272,0.00001633284,0.0000244575,0.00003145435],"domain_scores_gemma":[0.9998863,0.00001524889,0.00004721808,0.0000113182,0.0000113884,0.00002854016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001899632,0.0001075057,0.01146555,0.0001480481,0.00003458609,0.00102903,0.0001142986,0.0001575872,0.9717706,0.0006929856,0.0004947456,0.0120854],"study_design_scores_gemma":[0.0008636119,0.003590157,0.4103839,0.0001287354,0.0003229029,0.01624162,0.001343348,0.002510607,0.5140654,0.003516592,0.04696809,0.00006495514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882615,0.008750368,0.000881265,0.0004140013,0.00003946447,0.00001600173,0.0001385465,0.00004120162,0.001457653],"genre_scores_gemma":[0.9950749,0.00287808,0.000236299,0.000135995,0.00003555998,0.00001962667,0.000174096,0.000004991442,0.001440331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274582,"threshold_uncertainty_score":0.004263937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005306004316747828,"score_gpt":0.2109816671239819,"score_spread":0.2056756628072341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}