{"id":"W2004548214","doi":"10.7326/0003-4819-148-3-200802050-00019","title":"Translation of Genetic Discoveries into Clinical Therapies","year":2008,"lang":"en","type":"letter","venue":"Annals of Internal Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Eye Institute","keywords":"Medicine; Translation (biology); Clinical trial; MEDLINE; Intensive care medicine; Bioinformatics; Computational biology; Pathology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002615686,0.0005277829,0.001090531,0.0004271022,0.001852353,0.00232493,0.001023494,0.02848646,0.003590466],"category_scores_gemma":[0.01579245,0.0004208909,0.0007197212,0.0003138704,0.003349987,0.001895032,0.001062606,0.02980918,0.003462382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002088413,"about_ca_system_score_gemma":0.001698691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008662867,"about_ca_topic_score_gemma":0.001880951,"domain_scores_codex":[0.998046,0.0008064624,0.0001227944,0.0001857476,0.0006181169,0.0002209149],"domain_scores_gemma":[0.9948117,0.003532041,0.0002182342,0.0001875408,0.0005907673,0.0006596975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001009953,0.00004560801,0.0003904613,0.00004020987,0.00001819925,0.002046313,0.00009196655,0.00008234988,0.0002562337,0.004728911,0.98318,0.009018725],"study_design_scores_gemma":[0.000258664,0.0001407671,0.001000546,0.0001489661,0.00004083143,0.00288719,0.0002644415,0.0007325436,0.0006566124,0.02229384,0.9715262,0.00004948634],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004659219,0.001374537,0.0001417404,0.9765014,0.01815081,0.000006146977,0.00002046908,0.00002984489,0.003309124],"genre_scores_gemma":[0.01054396,0.001487686,0.0003414053,0.9322136,0.04658904,0.0000292863,0.0000195105,0.00001729118,0.0087581],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02848646,"threshold_uncertainty_score":0.01515257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04510914697278569,"score_gpt":0.3954192441904699,"score_spread":0.3503100972176842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}