{"id":"W2004551960","doi":"10.1002/ijc.20324","title":"DNA binding sites for putative methylation boundaries in the unmethylated region of the <i>BRCA1</i> promoter","year":2004,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"CTCF; DNA methylation; Epigenetics of physical exercise; Methylation; Biology; Promoter; CpG site; Epigenetics; Molecular biology; Carcinogenesis; Tumor suppressor gene; Transcription (linguistics); Gene; Transcription factor; Gene expression; Genetics; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552542,0.0001853639,0.0002182421,0.0003489888,0.0002953792,0.0002609608,0.0003369836,0.0003911951,0.003156833],"category_scores_gemma":[0.0004908181,0.0002517442,0.0002404367,0.0001615215,0.000256715,0.0001644851,0.000257941,0.0004056828,0.001258679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993317,"about_ca_system_score_gemma":0.0002923646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114986,"about_ca_topic_score_gemma":0.001822427,"domain_scores_codex":[0.9998507,0.00002566683,0.000005643923,0.00004784186,0.00004385153,0.00002623133],"domain_scores_gemma":[0.9997067,0.00009690355,0.00007092591,0.0000175699,0.00003303669,0.00007488077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004742387,0.00005755655,0.003248799,0.0001497403,0.00001713798,0.0002339128,0.0001492524,0.0002205463,0.9879184,0.0005505735,0.0002270166,0.00675278],"study_design_scores_gemma":[0.0001486095,0.0005019162,0.1787224,0.0001397915,0.00006156605,0.001488812,0.0001776825,0.004751806,0.7996562,0.00148164,0.01281704,0.00005263853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790326,0.004658265,0.01172733,0.0001482872,0.00003629347,0.00004643944,0.000739263,0.0001955914,0.00341583],"genre_scores_gemma":[0.9911486,0.0004606058,0.005494826,0.0000747529,0.00001371031,0.00002770047,0.001373932,0.00001777272,0.001388076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003156833,"threshold_uncertainty_score":0.01056069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085997011774248,"score_gpt":0.3274339052129013,"score_spread":0.3065739350951588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}