{"id":"W2004551960","doi":"10.1002/ijc.20324","title":"DNA binding sites for putative methylation boundaries in the unmethylated region of the <i>BRCA1</i> promoter","year":2004,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance","keywords":"CTCF; DNA methylation; Epigenetics of physical exercise; Methylation; Biology; Promoter; CpG site; Epigenetics; Molecular biology; Carcinogenesis; Tumor suppressor gene; Transcription (linguistics); Gene; Transcription factor; Gene expression; Genetics; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003921388,0.00006647276,0.00008595626,0.00006341375,0.00004975466,0.00004389675,0.0002650249,0.00005758772,0.000002642029],"category_scores_gemma":[0.0001896104,0.00004009613,0.0001083263,0.00008996251,0.00008808573,0.0000126723,0.0000259858,0.00008067281,1.354941e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005453683,"about_ca_system_score_gemma":0.0001930332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003164441,"about_ca_topic_score_gemma":0.0001207293,"domain_scores_codex":[0.9992293,0.00006500307,0.0003000788,0.00008051719,0.0002524382,0.0000727341],"domain_scores_gemma":[0.9989987,0.00004008388,0.0004104611,0.00007585975,0.0004624416,0.00001243134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002777918,0.00006261622,0.006734295,0.000009613532,0.0001846218,0.000002431743,0.001392122,0.005800471,0.9793025,0.0006217578,0.00009072497,0.005521087],"study_design_scores_gemma":[0.001167419,0.0001845663,0.01104134,0.00006646402,0.00003274302,0.000008717029,0.0001482141,0.0000363885,0.9693374,0.009256871,0.008655009,0.00006486306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860284,0.001631963,0.008775277,0.002837146,0.0004904944,0.000160579,0.00001656102,7.375666e-7,0.00005882116],"genre_scores_gemma":[0.9987487,0.0002516739,0.0005373568,0.0001396036,0.0002563478,0.000009765678,0.00001402708,0.00000724617,0.00003532941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272023,"threshold_uncertainty_score":0.1635073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085997011774248,"score_gpt":0.3274339052129013,"score_spread":0.3065739350951588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}