{"id":"W2004575367","doi":"10.1038/nn.3479","title":"Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Biology; Mutant; Cell biology; RNA; Gene; RNA-binding protein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002463665,0.0008474072,0.0003000846,0.0004316879,0.0007525209,0.000596457,0.0003667154,0.0005868605,0.002144453],"category_scores_gemma":[0.0002758555,0.0003905406,0.0007467467,0.0002722704,0.0003784338,0.0003262594,0.0004101842,0.001050212,0.0009045032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000770512,"about_ca_system_score_gemma":0.0003851349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002296679,"about_ca_topic_score_gemma":0.00211048,"domain_scores_codex":[0.9998177,0.00001403526,0.00001164772,0.00005239456,0.00006431968,0.00003992797],"domain_scores_gemma":[0.999804,0.00001794267,0.00006059965,0.00002167414,0.00002585203,0.00007007582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000177095,0.00002269962,0.001063558,0.00006329416,0.00005180957,0.0005352448,0.00001834977,0.0001339576,0.9942238,0.0003172048,0.0006599742,0.002733091],"study_design_scores_gemma":[0.0000421185,0.000135053,0.006386898,0.000009702483,0.00004663148,0.001662256,0.00003183152,0.0006857479,0.9853328,0.0002624268,0.005393321,0.00001111337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622235,0.009384673,0.01537777,0.001436696,0.0007652573,0.00009359583,0.002441698,0.001230553,0.007046326],"genre_scores_gemma":[0.9861077,0.002498824,0.005137253,0.0002226415,0.00004902693,0.00002708567,0.0009910624,0.00009058476,0.004875819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296679,"threshold_uncertainty_score":0.007173896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0097564337711349,"score_gpt":0.2570187724222645,"score_spread":0.2472623386511296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}