{"id":"W2004575367","doi":"10.1038/nn.3479","title":"Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation","year":2013,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Biology; Mutant; Cell biology; RNA; Gene; RNA-binding protein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267003,0.0001356797,0.00009240372,0.00006585676,0.0001626816,0.0001912615,0.0004002758,0.0001637535,0.00002284279],"category_scores_gemma":[0.0001115752,0.00009979135,0.0000275099,0.0002821724,0.00006728452,0.00008218503,0.0001082752,0.0003279491,0.00001907802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001395063,"about_ca_system_score_gemma":0.00004801324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002643344,"about_ca_topic_score_gemma":0.00001326791,"domain_scores_codex":[0.9986809,0.00003875643,0.00009699866,0.0004460329,0.0003560491,0.0003812688],"domain_scores_gemma":[0.9991815,0.000003440635,0.00004471209,0.0004156384,0.00009921336,0.0002554831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002797242,0.0000326216,0.0001325285,0.00001021587,0.0000011097,0.00001680249,0.0000424014,0.00003131626,0.9961674,0.000009213677,0.0005624155,0.002966061],"study_design_scores_gemma":[0.0002371496,0.00136106,0.005712448,0.00005527488,0.000002040256,0.0001016154,0.00004778496,0.00118963,0.9883249,0.00002879562,0.002724761,0.0002145569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964751,0.00008138797,0.001129691,0.001327179,0.00005700117,0.0007923935,0.000005523619,0.00001984132,0.0001118802],"genre_scores_gemma":[0.9948496,0.00001221458,0.0008361053,0.002954293,0.00003782416,0.0001047166,0.000009647866,0.00001346604,0.001182098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007842458,"threshold_uncertainty_score":0.4069373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0097564337711349,"score_gpt":0.2570187724222645,"score_spread":0.2472623386511296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}