{"id":"W2004579769","doi":"10.1073/pnas.0804919105","title":"In vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the <i>Escherichia coli</i> O157 AB <sub>5</sub> toxins","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Avidity; Escherichia coli; Effector; Ligand (biochemistry); Chemistry; Receptor; In vivo; Cell biology; Biochemistry; Supramolecular chemistry; Scaffold protein; Linker; Computational biology; Biophysics; Combinatorial chemistry; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008394119,0.0002201202,0.0001496725,0.00006627588,0.00008492305,0.0001839503,0.0001214164,0.0001704876,0.0008470559],"category_scores_gemma":[0.00008435766,0.00006931979,0.0001136684,0.00005041044,0.0001969815,0.0001233296,0.0001584281,0.0003590413,0.0002023529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356796,"about_ca_system_score_gemma":0.0000879285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001269505,"about_ca_topic_score_gemma":0.0001928315,"domain_scores_codex":[0.9999429,0.000008966758,0.000002851026,0.000013348,0.00001410456,0.00001791467],"domain_scores_gemma":[0.9999563,0.000009964467,0.0000150496,0.000004682748,0.000003437498,0.00001068266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002484441,0.000009774781,0.00003813538,0.000008147967,0.000001438983,0.00001252704,0.000005001868,0.00007917976,0.9987675,0.00009923056,0.00001642054,0.0009377948],"study_design_scores_gemma":[0.000005240795,0.0001033721,0.0002110793,6.805504e-7,0.000005121838,0.00006311964,0.000002959138,0.0003819042,0.998566,0.00002393892,0.0006352869,0.000001329097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987559,0.0007578606,0.009474405,0.0001471122,0.00001912105,0.00001841223,0.00003339876,0.0001205765,0.001870098],"genre_scores_gemma":[0.9966385,0.0002098533,0.002282477,0.00004567218,0.000006374516,0.00001029986,0.0000202763,0.00001375212,0.0007727487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008470559,"threshold_uncertainty_score":0.002833664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239019658995848,"score_gpt":0.2713187387311869,"score_spread":0.2474167728316022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}