{"id":"W2004584037","doi":"10.1016/j.bmcl.2009.09.099","title":"A new approach to the synthesis of polyunsaturated deuterated isoprostanes: Total synthesis of d4-5-epi-8,12-iso-iPF3α-VI and d4-8,12-iso-iPF3α-VI","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Chemistry; Isoprostanes; Eicosapentaenoic acid; Synthon; Docosahexaenoic acid; Polyunsaturated fatty acid; Population; Oxidative stress; Biochemistry; Fatty acid; Stereochemistry; Lipid peroxidation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004319452,0.0007761103,0.0005011719,0.000558939,0.0004239822,0.0003661926,0.0006156297,0.0004646411,0.001994144],"category_scores_gemma":[0.0002283235,0.0002324529,0.0005345484,0.0003939365,0.0003697327,0.0005193724,0.0005185666,0.001133963,0.0009140148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004425384,"about_ca_system_score_gemma":0.0008684758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006623688,"about_ca_topic_score_gemma":0.0009425989,"domain_scores_codex":[0.9998631,0.00001853222,0.00001588371,0.00003946598,0.00002595658,0.00003700167],"domain_scores_gemma":[0.9998441,0.00002171597,0.00001848485,0.00003183544,0.00003759866,0.00004638854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000443626,0.0001008578,0.0001622272,0.000271215,0.00005274325,0.0002364237,0.0001238923,0.0004686568,0.9741186,0.002655214,0.0002600822,0.02110643],"study_design_scores_gemma":[0.00007552667,0.0006280066,0.0002758038,0.00001299033,0.00005793896,0.0002852133,0.00002721212,0.0005277162,0.983381,0.000827753,0.01387137,0.00002948061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4614436,0.007655655,0.5060183,0.0009948842,0.001335892,0.0007787721,0.002397763,0.0006963079,0.01867882],"genre_scores_gemma":[0.8224402,0.009526815,0.1469906,0.0004691484,0.0001670446,0.0005370071,0.002986742,0.000199669,0.01668268],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001994144,"threshold_uncertainty_score":0.006671011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020596726601759,"score_gpt":0.2251996729582651,"score_spread":0.2149937056922475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}