{"id":"W2004584509","doi":"10.1002/bdra.20333","title":"Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects","year":2006,"lang":"en","type":"review","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Exencephaly; Neural tube; Biology; Genetics; Ciliopathies; Neural tube defect; Mutant; Penetrance; Anencephaly; Spina bifida; Heterozygote advantage; Neurulation; Neural fold; Cilium; Gene; Neural plate; Phenotype; Allele; Embryo; Gastrulation; Fetus; Teratology; Embryogenesis; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009472526,0.0006749009,0.0004375548,0.001127989,0.000142153,0.0003913284,0.0006254018,0.0009944884,0.001150718],"category_scores_gemma":[0.0004902009,0.0002602169,0.0002863109,0.000326673,0.0007235084,0.0006906389,0.0003613094,0.000793824,0.0002830037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325444,"about_ca_system_score_gemma":0.0002257792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930678,"about_ca_topic_score_gemma":0.0003214718,"domain_scores_codex":[0.9997885,0.0000659595,0.00003383677,0.00004304606,0.00005223378,0.00001649019],"domain_scores_gemma":[0.9997594,0.00008379167,0.00009533639,0.00002164644,0.00002058466,0.00001924044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007420136,0.0003839831,0.01831666,0.003053666,0.0001689799,0.005701497,0.0006050635,0.001697439,0.7614713,0.0288414,0.006250345,0.1727678],"study_design_scores_gemma":[0.0003718621,0.003386789,0.1570057,0.004160776,0.001131701,0.1072203,0.0009785561,0.01123966,0.3026879,0.03401709,0.3776166,0.000183155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4319452,0.4417633,0.09938281,0.01070333,0.0007055934,0.0002361845,0.001351937,0.001450676,0.0124609],"genre_scores_gemma":[0.6788672,0.2363736,0.07566341,0.002277098,0.0004810196,0.0004569651,0.001135407,0.0001258873,0.004619469],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001150718,"threshold_uncertainty_score":0.005009592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1764021912966298,"score_gpt":0.4440719626860469,"score_spread":0.2676697713894172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}