{"id":"W2004593599","doi":"10.1089/adt.2006.039","title":"Capture Compound Mass Spectrometry: A Technology for the Investigation of Small Molecule Protein Interactions","year":2007,"lang":"en","type":"article","venue":"Assay and Drug Development Technologies","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Automotive Partnership Council","funders":"","keywords":"Chemistry; Proteome; Function (biology); Mass spectrometry; Small molecule; Computational biology; Drug discovery; Drug; Drug target; Combinatorial chemistry; Proteomics; Drug development; Molecule; Biochemistry; Gene; Biology; Chromatography; Pharmacology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008879898,0.001090995,0.0009100135,0.001262415,0.0006983003,0.0008180318,0.0008565166,0.001289142,0.00257243],"category_scores_gemma":[0.0006386334,0.0004041311,0.0003659176,0.0007723255,0.0007984362,0.001117164,0.0006709101,0.001443459,0.00139502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006217231,"about_ca_system_score_gemma":0.0005898142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236142,"about_ca_topic_score_gemma":0.0006419956,"domain_scores_codex":[0.9993592,0.0001004828,0.0000208228,0.0001538093,0.0003218847,0.00004380632],"domain_scores_gemma":[0.9995735,0.000181265,0.00008805553,0.00004593634,0.00006333595,0.00004784475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017301,0.00004465302,0.000453276,0.0002183625,0.00003926975,0.0001002757,0.00002865746,0.00009113682,0.9771627,0.001938409,0.001251458,0.01856998],"study_design_scores_gemma":[0.00004738651,0.0003269294,0.001561167,0.00002203562,0.0000343447,0.001102934,0.00003176859,0.002812148,0.9743392,0.001117682,0.01857731,0.00002705505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2435935,0.03637649,0.6912428,0.003784924,0.0007546235,0.0009251988,0.003180837,0.005239205,0.01490251],"genre_scores_gemma":[0.5324812,0.03350819,0.4075047,0.003235994,0.000652762,0.001146662,0.003628987,0.0003660078,0.01747559],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00257243,"threshold_uncertainty_score":0.008605599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422749813542325,"score_gpt":0.2454594112011139,"score_spread":0.2312319130656906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}