{"id":"W2004603206","doi":"10.1016/j.bmc.2008.07.060","title":"Stress-driven discovery of metabolites from the phytopathogenic fungus Leptosphaeria maculans: Structure and activity of leptomaculins A–E","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Leptosphaeria maculans; Chemistry; Fungus; Pathogenic fungus; Stereochemistry; Phytotoxin; Biosynthesis; Chemical structure; Metabolic pathway; Biochemistry; Ascomycota; Toxin; Metabolism; Botany; Enzyme; Organic chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008683422,0.0002891955,0.0004063055,0.000009826326,0.00009274921,0.000008400003,0.0004012953,0.0002861156,0.00009662224],"category_scores_gemma":[0.0002019848,0.0002027527,0.0001404808,0.0001212166,0.0005725336,0.00001038558,0.0001770173,0.000181237,5.461742e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001097467,"about_ca_system_score_gemma":0.0001681775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006849247,"about_ca_topic_score_gemma":0.00001000669,"domain_scores_codex":[0.9986519,0.00004859051,0.0003165276,0.0004522036,0.0002855485,0.0002452564],"domain_scores_gemma":[0.9989441,0.00007656992,0.0002888707,0.0005147713,0.00007780626,0.00009787791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002121188,0.00007494583,0.03024849,0.0001275799,0.0002043051,0.00001144943,0.00007214326,0.000001124284,0.9685469,0.000001221329,0.0001798299,0.0003198633],"study_design_scores_gemma":[0.0004986353,0.00005273246,0.03793511,0.00008146936,0.0001661456,0.0001273456,0.0001465581,0.00000849928,0.9603856,0.00001027458,0.0003840237,0.0002036493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904104,0.006701841,0.00005205199,0.0001128198,0.00006567467,0.0001060323,0.002461835,0.00001017603,0.00007913267],"genre_scores_gemma":[0.9975343,0.001195221,0.0001192961,0.00004877746,0.0004987136,0.000003696012,0.0004391214,0.00001998567,0.0001408437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008161366,"threshold_uncertainty_score":0.8268014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008473508178068363,"score_gpt":0.2069082572726203,"score_spread":0.198434749094552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}