{"id":"W2004603206","doi":"10.1016/j.bmc.2008.07.060","title":"Stress-driven discovery of metabolites from the phytopathogenic fungus Leptosphaeria maculans: Structure and activity of leptomaculins A–E","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Leptosphaeria maculans; Chemistry; Fungus; Pathogenic fungus; Stereochemistry; Phytotoxin; Biosynthesis; Chemical structure; Metabolic pathway; Biochemistry; Ascomycota; Toxin; Metabolism; Botany; Enzyme; Organic chemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107389,0.0003171119,0.0001530144,0.0002509718,0.0001828027,0.0002810736,0.0001241342,0.0002654529,0.0005058882],"category_scores_gemma":[0.0001344254,0.0001004282,0.0001311766,0.0002212756,0.0001361137,0.0002307856,0.0001771546,0.0002899125,0.0001154754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176477,"about_ca_system_score_gemma":0.0002568161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008559366,"about_ca_topic_score_gemma":0.001547204,"domain_scores_codex":[0.9999613,0.000006662583,0.000003597596,0.000009058495,0.000009567202,0.000009937811],"domain_scores_gemma":[0.9999161,0.00001580534,0.00001727554,0.000008774192,0.00001578427,0.00002634748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001538469,0.00001141342,0.0002942603,0.00002181447,0.000003440973,0.00007799071,0.0000100161,0.00007780106,0.997744,0.00004107709,0.00002009543,0.001544366],"study_design_scores_gemma":[0.00001776585,0.0002221243,0.005978892,0.0000053157,0.00001156984,0.0001689082,0.00004216334,0.0002959564,0.9915692,0.00006341359,0.001619775,0.000004876844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956964,0.001282145,0.001420832,0.0001037756,0.0000118853,0.00002988049,0.0005185927,0.0000258675,0.0009105802],"genre_scores_gemma":[0.9961288,0.0007890761,0.001445035,0.00006504857,0.00000455387,0.00001287159,0.0006984862,0.000009753131,0.0008464586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008559366,"threshold_uncertainty_score":0.001701891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008473508178068363,"score_gpt":0.2069082572726203,"score_spread":0.198434749094552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}