{"id":"W2004637416","doi":"10.1016/j.tim.2009.08.005","title":"Are essential genes really essential?","year":2009,"lang":"en","type":"article","venue":"Trends in Microbiology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Biology; Gene; Genome; Genetics; Context (archaeology); Computational biology; Phenotype; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009997161,0.000191462,0.0002376279,0.0001189847,0.00005869558,0.00001078981,0.000315616,0.0002069853,0.00004958587],"category_scores_gemma":[0.00002053519,0.0001833015,0.0001001955,0.000124225,0.000106742,5.160255e-7,0.0001465221,0.00008267366,0.00001309279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001076123,"about_ca_system_score_gemma":0.00001843822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001702524,"about_ca_topic_score_gemma":0.0003363215,"domain_scores_codex":[0.9988688,0.00006656162,0.0002469012,0.0004404778,0.00002475473,0.0003525556],"domain_scores_gemma":[0.9993653,0.000006259477,0.0001253319,0.0004245707,0.00003918645,0.00003938633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006329441,0.00007425472,0.004896077,0.00000240414,0.00003602384,0.00001102333,0.00003343458,0.00004258664,0.9814169,0.0000759278,0.004861395,0.008486679],"study_design_scores_gemma":[0.00166189,0.0005389461,0.1795274,0.00001360534,0.0000402356,0.000136691,0.0001014548,0.000006639836,0.7156773,0.0006199534,0.1010336,0.0006422641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936469,0.003293694,0.00005721061,0.0007458515,0.000294324,0.00005740232,0.00004579259,0.000006233051,0.001852622],"genre_scores_gemma":[0.9968265,0.0004996466,0.0006853166,0.0005885484,0.0003173855,0.000006635047,0.0001609541,0.00001329685,0.000901732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2657396,"threshold_uncertainty_score":0.7474819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987294378425692,"score_gpt":0.2596633120966559,"score_spread":0.249790368312399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}