{"id":"W2004682614","doi":"10.3816/clc.2006.s.005","title":"Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer: Impact of Primary or Secondary Mutations","year":2006,"lang":"en","type":"review","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Erlotinib; Gefitinib; Medicine; Lung cancer; Epidermal growth factor receptor; T790M; Oncology; Internal medicine; Tyrosine kinase; Erlotinib Hydrochloride; Clinical trial; Cancer; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003224524,0.0008048758,0.00408292,0.0004673689,0.0000986707,0.00003207045,0.0002524606,0.0007671128,0.002656503],"category_scores_gemma":[0.0003572723,0.0005390261,0.001856711,0.00106681,0.0003128105,0.0002168758,0.0001035821,0.001277155,0.00001429508],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.00429968,"about_ca_system_score_gemma":0.01314064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004449066,"about_ca_topic_score_gemma":0.000791712,"domain_scores_codex":[0.9946561,0.0003308443,0.002943273,0.0009771462,0.0004415838,0.0006510146],"domain_scores_gemma":[0.9960984,0.001197076,0.001305457,0.000603469,0.000354436,0.0004411356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003346909,0.001114184,0.07084663,0.03302899,0.003041939,0.0001383363,0.0001076227,0.00002169545,0.000003021356,0.0000117686,0.07614461,0.8152065],"study_design_scores_gemma":[0.0113029,0.00134429,0.09632686,0.08271405,0.02044276,0.00004942223,0.00002096869,0.0001007776,0.00001466592,0.00001690709,0.7859734,0.001692985],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002442923,0.984683,0.0000103138,0.0002641944,0.001787163,0.003520041,0.006006612,0.0000793771,0.001206362],"genre_scores_gemma":[0.0009416236,0.9893218,0.0003139416,0.0002275815,0.00177958,0.001510326,0.002571439,0.0001790585,0.003154627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8135135,"threshold_uncertainty_score":0.9997061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05832898923244735,"score_gpt":0.4730369604921097,"score_spread":0.4147079712596624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}