{"id":"W2004730219","doi":"10.1038/nrneph.2014.201","title":"Mechanisms and biological functions of autophagy in diseased and ageing kidneys","year":2014,"lang":"en","type":"review","venue":"Nature Reviews Nephrology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Autophagy; Cell biology; Autophagosome; Homeostasis; Inflammation; Programmed cell death; Cytoplasm; Podocyte; Immune system; Mitochondrion; Biology; Kidney; Apoptosis; Medicine; Immunology; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005937034,0.0004723331,0.003891134,0.0003183607,0.00004545413,0.000006920447,0.0001308729,0.001531205,0.0001720158],"category_scores_gemma":[0.0004181297,0.0002997398,0.0004621379,0.0003301686,0.0002145427,0.00002948626,0.00009451074,0.00122225,0.00002050891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000365064,"about_ca_system_score_gemma":0.0001593908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003633877,"about_ca_topic_score_gemma":0.000002760355,"domain_scores_codex":[0.9973386,0.0007087933,0.0009130845,0.0006157545,0.0001143316,0.0003094503],"domain_scores_gemma":[0.998455,0.0003173416,0.000470171,0.0004635738,0.00003566922,0.0002582291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005362683,0.0001127038,0.00002280225,0.01932912,0.0001883424,0.0001656471,0.00001051156,1.522454e-8,0.00003370156,0.002800997,0.0007966853,0.9764858],"study_design_scores_gemma":[0.0007064219,0.0003116968,0.001081734,0.006249982,0.001270912,0.0002019411,0.000001583073,0.000006669993,7.86516e-7,0.0008259329,0.9891319,0.0002104469],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001634429,0.9974476,0.0001397913,0.0001110843,0.0001656854,0.001689948,0.00003814703,0.00003389471,0.0002104468],"genre_scores_gemma":[0.0003320436,0.9962813,0.0004201587,0.00228167,0.0001598744,0.0002063355,0.000196244,0.00003532799,0.00008699059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9883352,"threshold_uncertainty_score":0.9999455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03033714896923169,"score_gpt":0.3499342610051313,"score_spread":0.3195971120358996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}