{"id":"W2004740514","doi":"10.1074/jbc.m114.597930","title":"Functional Characterization of CaVα2δ Mutations Associated with Sudden Cardiac Death","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Mutant; Wild type; Gating; Protein subunit; Molecular biology; Patch clamp; Cell biology; HEK 293 cells; Mutation; Flow cytometry; Biology; Chemistry; Gene; Biophysics; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379086,0.0002815046,0.0002094699,0.0003072485,0.0001200587,0.0001961967,0.0001514925,0.000301798,0.0007296358],"category_scores_gemma":[0.0002945662,0.00008077107,0.0002638212,0.0001706577,0.0002118437,0.00008543558,0.0001190758,0.0002154273,0.000253546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001705201,"about_ca_system_score_gemma":0.00007288908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004776847,"about_ca_topic_score_gemma":0.0003348814,"domain_scores_codex":[0.9998766,0.00001689262,0.00002167087,0.00003132819,0.0000349669,0.00001850792],"domain_scores_gemma":[0.9998703,0.00002786008,0.00003613193,0.000009941969,0.00002360597,0.00003215195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002569461,0.00004737526,0.003920642,0.00002952006,0.00001449393,0.001254863,0.00005185944,0.0001048335,0.9929832,0.00006439379,0.00005014998,0.001221695],"study_design_scores_gemma":[0.0001565298,0.001492317,0.2632096,0.00003295031,0.0001480878,0.0280324,0.0003134421,0.006460935,0.6948699,0.0003016431,0.004944122,0.00003806839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988512,0.0001774968,0.0004097879,0.00002257452,0.00001338561,0.00001249605,0.0002411425,0.000009985619,0.0002619947],"genre_scores_gemma":[0.9986383,0.0001215422,0.0003239459,0.00003192171,0.000006573128,0.000009682119,0.0005255555,0.00001136445,0.0003310517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007296358,"threshold_uncertainty_score":0.002440929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448290727616769,"score_gpt":0.229833333486036,"score_spread":0.2153504262098683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}