{"id":"W2004749966","doi":"10.1016/j.bbalip.2011.08.014","title":"The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1","year":2011,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Agonist; Liver X receptor; Central nervous system; Neuroscience; Medicine; Internal medicine; Endocrinology; Biology; Receptor; Transporter; Nuclear receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537299,0.0005353719,0.0005111163,0.0004399884,0.0003100729,0.000524947,0.0002379434,0.0005457868,0.001873537],"category_scores_gemma":[0.0001937737,0.000277953,0.0004384092,0.0003111891,0.0005348261,0.0004203636,0.0003024608,0.001435978,0.0006140428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004977811,"about_ca_system_score_gemma":0.0006107937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433967,"about_ca_topic_score_gemma":0.002898304,"domain_scores_codex":[0.9998415,0.00002118107,0.00001817543,0.00002978399,0.00002693265,0.00006251836],"domain_scores_gemma":[0.9998561,0.00001451043,0.00004393431,0.00001475301,0.00001340259,0.00005727995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002819714,0.0001566395,0.0004150876,0.0001306953,0.00004750095,0.0003545949,0.00003259214,0.00005211141,0.9907095,0.0001901174,0.0006152407,0.004476194],"study_design_scores_gemma":[0.000647404,0.002673057,0.02005231,0.0000471065,0.000192194,0.001298721,0.0002775974,0.0007016913,0.9699322,0.0005481033,0.003600942,0.00002864659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943824,0.002200706,0.0005329759,0.0006578381,0.0001579241,0.0000142216,0.0004675614,0.0001816745,0.001404708],"genre_scores_gemma":[0.9919991,0.002805852,0.0008898673,0.0002762296,0.00005070153,0.00006146845,0.0006498436,0.0000387317,0.003228241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873537,"threshold_uncertainty_score":0.006267548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634762904877152,"score_gpt":0.234998646581889,"score_spread":0.2186510175331175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}