{"id":"W2004764415","doi":"10.1074/jbc.m204796200","title":"A New Type of High Affinity Folic Acid Transporter in the Protozoan Parasite Leishmania and Deletion of Its Gene in Methotrexate-resistant Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"","keywords":"Transporter; Biochemistry; Biology; Antifolate; Leishmania; Pteridine; Mutant; Leishmania major; Methotrexate; Gene; Auxotrophy; Parasite hosting; Enzyme; Antimetabolite; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007432348,0.0001175507,0.0005226893,0.00005599663,0.00001442606,0.000005304455,0.0001531767,0.0001367585,0.0001688184],"category_scores_gemma":[0.0003219098,0.00006435487,0.00009169565,0.0002578388,0.000103264,0.00003795694,0.00002223991,0.0003966017,7.833326e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003748932,"about_ca_system_score_gemma":0.00003954642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002855065,"about_ca_topic_score_gemma":0.00001032912,"domain_scores_codex":[0.9986771,0.0001106526,0.000609303,0.0001330961,0.0002888259,0.0001809893],"domain_scores_gemma":[0.9992012,0.0001362848,0.0002956249,0.0001248327,0.0001569403,0.00008513763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008728071,0.0002927979,0.02818688,0.0001994553,0.00004597817,0.0001535725,0.0002716072,0.000002241534,0.9688197,0.000004833615,0.0001260053,0.001024129],"study_design_scores_gemma":[0.001327284,0.0006896473,0.3134102,0.0001637495,0.00002832933,0.00007918288,0.0001197535,0.000008094745,0.6839092,0.00009344475,0.0001146989,0.000056375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996215,0.002469367,0.00001404182,0.0007407395,0.00001063952,0.000267949,0.000006067829,0.000002354371,0.0002738454],"genre_scores_gemma":[0.9965692,0.002342472,0.0009380642,0.00004254307,0.00005553629,0.000005354263,0.000001724988,0.000004785637,0.00004035231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2852234,"threshold_uncertainty_score":0.2624315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07541267388768386,"score_gpt":0.3152371985622396,"score_spread":0.2398245246745558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}