{"id":"W2004777236","doi":"10.1021/np020375t","title":"Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues","year":2002,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Antimitotic Agent; Natural product; Tripeptide; Chemistry; Stereochemistry; In vitro; Biological activity; Chemical synthesis; Cytotoxic T cell; Structure–activity relationship; Combinatorial chemistry; Pharmacology; Biology; Biochemistry; Peptide; Tubulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580344,0.0002674377,0.0002080624,0.0002239361,0.0001509805,0.0002021435,0.0002634419,0.000170609,0.002300688],"category_scores_gemma":[0.0002368682,0.0001021493,0.0001624456,0.0002143992,0.0001568016,0.0001786789,0.0001471444,0.0004022043,0.0004820468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666677,"about_ca_system_score_gemma":0.0002104321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002373703,"about_ca_topic_score_gemma":0.0004917887,"domain_scores_codex":[0.9999262,0.00001842417,0.00001492299,0.00001376523,0.00001486657,0.0000118489],"domain_scores_gemma":[0.9998686,0.00002401007,0.0000352163,0.00001393065,0.0000236182,0.00003469798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004878547,0.00005776181,0.0001550092,0.0002586341,0.0000146636,0.0003853372,0.00005618942,0.0008474407,0.9839317,0.0006125556,0.0001782678,0.01301472],"study_design_scores_gemma":[0.0001938244,0.002137276,0.001274308,0.00003152136,0.00004382585,0.0009373561,0.0000474095,0.0004250571,0.9811018,0.000142598,0.01364717,0.00001785504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777892,0.006906139,0.004351547,0.0002174888,0.00009036139,0.0002177777,0.001140523,0.0000853987,0.009201576],"genre_scores_gemma":[0.9772394,0.00589781,0.01025038,0.0001796942,0.0000338511,0.0001611217,0.00172594,0.00002468843,0.004487102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300688,"threshold_uncertainty_score":0.007696569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394763312712544,"score_gpt":0.2300470128044112,"score_spread":0.2160993796772858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}