{"id":"W2004777236","doi":"10.1021/np020375t","title":"Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues","year":2002,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Antimitotic Agent; Natural product; Tripeptide; Chemistry; Stereochemistry; In vitro; Biological activity; Chemical synthesis; Cytotoxic T cell; Structure–activity relationship; Combinatorial chemistry; Pharmacology; Biology; Biochemistry; Peptide; Tubulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002966512,0.0001447335,0.0002861595,0.00009357673,0.00003824643,0.00001501261,0.000164852,0.00009237569,0.00001378033],"category_scores_gemma":[0.001028124,0.0001051016,0.00008646248,0.0001525408,0.00009240545,0.00002116222,0.00009097403,0.00023806,0.000001039431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008199268,"about_ca_system_score_gemma":0.00002194821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004119434,"about_ca_topic_score_gemma":0.000002613885,"domain_scores_codex":[0.9990693,0.00006833162,0.0002841755,0.0002231132,0.0001893339,0.0001657504],"domain_scores_gemma":[0.9989886,0.00002979001,0.0003666016,0.0002240819,0.0003306018,0.00006028261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172067,0.0000826316,0.0009031429,0.00009495208,0.00008569974,0.000009748304,0.00002361838,0.000004473737,0.9678962,0.000005236241,0.003396295,0.02732596],"study_design_scores_gemma":[0.0003188675,0.0003563789,0.01159799,0.00004153226,0.00004692172,0.0002930048,0.00001114605,0.00006070202,0.9846236,0.00001687231,0.002498462,0.0001345178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98814,0.009681129,0.000003471272,0.00160563,0.0003556959,0.00008722483,0.00000407984,0.000002763008,0.0001200274],"genre_scores_gemma":[0.9964707,0.001342584,0.0008276423,0.00004531387,0.0006572364,4.285526e-7,0.000001774379,0.00001150983,0.000642769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02719144,"threshold_uncertainty_score":0.4285918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394763312712544,"score_gpt":0.2300470128044112,"score_spread":0.2160993796772858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}