{"id":"W2004778693","doi":"10.1158/1538-7445.am2013-3314","title":"Abstract 3314: Sensitization of human tumor cells to chemotherapy drugs by antisense downregulation of BRCA2 and thymidylate synthase (TS): Induction of synthetic lethality by targeting DNA repair.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Synthetic lethality; Olaparib; Cisplatin; Cancer research; DNA repair; Biology; Homologous recombination; PARP inhibitor; Cancer cell; Genome instability; Gene knockdown; DNA damage; Thymidylate synthase; Cancer; Poly ADP ribose polymerase; Molecular biology; Polymerase; DNA; Chemotherapy; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294641,0.0004321657,0.0002755827,0.0001594483,0.0001405842,0.000183784,0.0001853418,0.0002942468,0.004039232],"category_scores_gemma":[0.00009464204,0.0001540534,0.0002267046,0.0001170388,0.0001405222,0.0001063325,0.0001198503,0.000616528,0.0007678223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942973,"about_ca_system_score_gemma":0.0002686839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009104607,"about_ca_topic_score_gemma":0.0009514467,"domain_scores_codex":[0.9998806,0.00002152322,0.0000135075,0.00002631832,0.0000334667,0.00002465958],"domain_scores_gemma":[0.9999373,0.00002020925,0.00001117442,0.00001060386,0.00000793967,0.00001272359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001725353,0.00007090998,0.00005331989,0.00003223653,0.000006145219,0.00004153067,0.00001001449,0.00008563792,0.9979382,0.0001392265,0.0002944125,0.00115582],"study_design_scores_gemma":[0.00007030931,0.0006705884,0.001358418,0.000004257744,0.00001183294,0.0001745727,0.000007333003,0.0007756571,0.9935991,0.00004222907,0.003282482,0.000003217041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751486,0.003497723,0.007123538,0.0004708703,0.0002885681,0.0002371963,0.003501978,0.0003484479,0.009383234],"genre_scores_gemma":[0.9837087,0.001072501,0.003217476,0.00015043,0.00002441588,0.0002045032,0.003299778,0.00004647286,0.008275677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004039232,"threshold_uncertainty_score":0.01351255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203915024582677,"score_gpt":0.3331665376295911,"score_spread":0.3111273873837644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}