{"id":"W2004786310","doi":"10.1007/s00213-008-1172-1","title":"The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist","year":2008,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health; Stanley Medical Research Institute","keywords":"Dopamine receptor D2; Pharmacology; Agonist; Dopamine receptor D1; Catalepsy; Dopamine; Chemistry; Antipsychotic; Haloperidol; Partial agonist; Dopamine receptor D3; Clozapine; Internal medicine; Psychology; Endocrinology; Receptor; Medicine; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002193326,0.00033333,0.0003750479,0.0001455295,0.0007908675,0.00006208205,0.0007811411,0.0001209743,0.0002652845],"category_scores_gemma":[0.00008524443,0.0002645646,0.0001372936,0.000440177,0.001471675,0.0002275168,0.0001004164,0.0005779227,0.0001174217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000309172,"about_ca_system_score_gemma":0.00005764919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001305795,"about_ca_topic_score_gemma":0.000001782901,"domain_scores_codex":[0.9972404,0.0003125787,0.000623878,0.0007554065,0.0004141922,0.0006536065],"domain_scores_gemma":[0.9986904,0.0003095879,0.0002919352,0.0004224979,0.00008195253,0.0002036695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000685111,0.0001776608,0.003303108,0.00002464518,0.00001184732,0.0001301187,0.0001292919,0.000006416479,0.990369,0.00009127818,0.002390248,0.002681275],"study_design_scores_gemma":[0.004637399,0.0004318854,0.02065588,0.00002511657,0.00007636821,0.001660787,0.00004255511,0.0001178787,0.92791,0.00006061819,0.04386159,0.0005198632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927052,0.0003094028,0.00002621705,0.001339969,0.004376429,0.0006163626,0.00005318793,0.0001099626,0.0004632514],"genre_scores_gemma":[0.9954349,0.001709946,0.000168491,0.001980193,0.0002116478,0.00006126604,0.000002026288,0.00004706116,0.0003845166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06245894,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623158993781567,"score_gpt":0.3098537529381155,"score_spread":0.2836221630002998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}