{"id":"W2004790864","doi":"10.1016/j.bmc.2013.04.045","title":"Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin A analogues","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"CanBiocin (Canada); University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Native chemical ligation; Stereochemistry; Circular dichroism; Bacteriocin; Peptide; C-terminus; Folding (DSP implementation); Peptide sequence; Chemical synthesis; Peptide bond; Protein folding; Biochemistry; Antimicrobial; Amino acid; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380981,0.0001390376,0.0002130338,0.000017175,0.00002616644,0.000006170619,0.0001166971,0.0001960313,0.0001063217],"category_scores_gemma":[0.0002253124,0.0001176182,0.00004260692,0.00007674564,0.0001865541,0.000007663523,0.00005737883,0.00006897125,7.493693e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001556576,"about_ca_system_score_gemma":0.00009492788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003967622,"about_ca_topic_score_gemma":5.607378e-7,"domain_scores_codex":[0.9991038,0.00006048027,0.0002292358,0.0002464758,0.0002286818,0.0001312687],"domain_scores_gemma":[0.9992936,0.00002347405,0.0001908521,0.0001823881,0.0002419072,0.00006772883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008080586,0.00003331578,0.0002605304,0.0001418103,0.00003630434,3.307678e-7,0.00002654795,0.000001667812,0.9928877,4.231363e-7,0.0001053893,0.00642519],"study_design_scores_gemma":[0.0003749822,0.00005179822,0.00917305,0.00005226596,0.0000989164,0.00003389231,0.00002313442,0.0004249887,0.989622,0.00002555677,0.000005263647,0.0001141279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987851,0.0001976939,0.0006137422,0.0001023755,0.00002911798,0.0001667407,0.00001743279,0.000005234768,0.00008257817],"genre_scores_gemma":[0.9994592,0.00006438672,0.0002219684,0.00002070836,0.0001213756,0.00001269191,0.00006488325,0.000009947535,0.00002484474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00891252,"threshold_uncertainty_score":0.4796333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370545490663359,"score_gpt":0.2480630756734626,"score_spread":0.2243576207668291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}