{"id":"W2004790864","doi":"10.1016/j.bmc.2013.04.045","title":"Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin A analogues","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"CanBiocin (Canada); University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Native chemical ligation; Stereochemistry; Circular dichroism; Bacteriocin; Peptide; C-terminus; Folding (DSP implementation); Peptide sequence; Chemical synthesis; Peptide bond; Protein folding; Biochemistry; Antimicrobial; Amino acid; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090811,0.0002321008,0.0002106917,0.0001601266,0.0001244506,0.0002907867,0.000339206,0.0002546264,0.00106039],"category_scores_gemma":[0.0002971559,0.0001165991,0.0002063267,0.0001500822,0.0001666277,0.0001747738,0.00015761,0.0004439701,0.0002261373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002496639,"about_ca_system_score_gemma":0.0001999732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004405307,"about_ca_topic_score_gemma":0.0004477002,"domain_scores_codex":[0.9998701,0.00003095559,0.00001625333,0.00001883306,0.00003042407,0.00003348391],"domain_scores_gemma":[0.9998822,0.00001624448,0.00003591925,0.00001057091,0.0000221079,0.00003300659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004436411,0.0001337442,0.0001299711,0.00007423163,0.000009266216,0.0001405369,0.0000193594,0.0008276475,0.99413,0.0001836129,0.00005301727,0.003855055],"study_design_scores_gemma":[0.0001542279,0.002607839,0.0008813309,0.00001079046,0.00002912988,0.0002439945,0.00002563366,0.001328456,0.9914569,0.00004603944,0.003204369,0.00001127262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916557,0.001317319,0.004645339,0.00006906438,0.00003908271,0.0001539851,0.0002626935,0.00003791409,0.001818807],"genre_scores_gemma":[0.9921068,0.0007436224,0.005100276,0.0000505831,0.000008581411,0.00005291982,0.000358897,0.000008418481,0.001569922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106039,"threshold_uncertainty_score":0.00354737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370545490663359,"score_gpt":0.2480630756734626,"score_spread":0.2243576207668291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}