{"id":"W2004798418","doi":"10.1128/aac.48.7.2700-2703.2004","title":"Constitutive Activation of the <i>PDR16</i> Promoter in a <i>Candida albicans</i> Azole-Resistant Clinical Isolate Overexpressing <i>CDR1</i> and <i>CDR2</i>","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Stanford Bio-X","keywords":"Azole; Candida albicans; Biology; Gene; Microbiology; Efflux; Multiple drug resistance; Mutation; Downregulation and upregulation; Strain (injury); Molecular biology; Drug resistance; Antifungal; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527619,0.0003492111,0.0002585669,0.0001584261,0.0001056801,0.0003866944,0.000194773,0.000213546,0.001350012],"category_scores_gemma":[0.0002636108,0.0001671547,0.0003127738,0.0001745688,0.0002851945,0.0001610074,0.0002868412,0.0007046688,0.0006425691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003687469,"about_ca_system_score_gemma":0.0002936166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000930146,"about_ca_topic_score_gemma":0.0009999046,"domain_scores_codex":[0.9997856,0.00002944141,0.00002225837,0.00005332738,0.00006008047,0.00004929606],"domain_scores_gemma":[0.9997657,0.00006171759,0.00006674727,0.00004613019,0.0000250462,0.00003470552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003668507,0.00001491296,0.0001416182,0.00001466788,0.000001738701,0.00001811024,0.00001255247,0.00003597864,0.9992353,0.00004812504,0.00001954621,0.0004207928],"study_design_scores_gemma":[0.000009822765,0.00009979131,0.001626223,0.000006332481,0.000007326566,0.0002133401,0.00002489271,0.0005767551,0.9957572,0.00002399349,0.001649585,0.000004703373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902306,0.0005360157,0.005846992,0.0001165936,0.00003554852,0.00006347842,0.001067224,0.0001827787,0.001920725],"genre_scores_gemma":[0.9863399,0.0003070373,0.007315058,0.0000551981,0.00001228067,0.00005507138,0.002682376,0.00007768657,0.003155441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350012,"threshold_uncertainty_score":0.004516244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664782681473506,"score_gpt":0.2902121187811365,"score_spread":0.2735642919664014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}