{"id":"W2004800182","doi":"10.1182/blood-2007-10-115873","title":"Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Leukemia; Pharmacokinetics; Nausea; Internal medicine; Histone deacetylase inhibitor; Gastroenterology; Vomiting; Pharmacology; Oncology; Histone deacetylase; Histone; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002444773,0.0001881187,0.0002529623,0.0001026381,0.0001251965,0.000006892248,0.0003815804,0.0001467035,0.0000330193],"category_scores_gemma":[0.000117386,0.0001562724,0.0001081084,0.0003647861,0.0002357423,0.000005201312,0.0002250497,0.0002669492,0.00002549598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008501054,"about_ca_system_score_gemma":0.000302224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001773899,"about_ca_topic_score_gemma":0.0003776642,"domain_scores_codex":[0.9982702,0.0002068516,0.0003918995,0.0004249118,0.0003785243,0.000327612],"domain_scores_gemma":[0.9989215,0.00001612469,0.0001034306,0.0007633884,0.0001036809,0.00009193816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002577299,0.006916633,0.00525847,0.00001378338,0.00004325538,0.0001018422,0.0006184798,0.00002587611,0.9794606,0.000003976742,0.006899852,0.0003994925],"study_design_scores_gemma":[0.01217477,0.001702995,0.003181246,0.0000166866,0.00001899065,0.00007235785,0.0002540211,0.00000842295,0.9720086,0.000002763114,0.01035427,0.0002049085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975392,0.001034155,0.000005757929,0.00003119746,0.0001786372,0.0005423687,0.00001737993,0.00001053332,0.0006407679],"genre_scores_gemma":[0.9983559,0.00008137282,0.00008842038,0.00002795304,0.000202426,0.00003997817,0.00001905692,0.00003459732,0.001150319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01191704,"threshold_uncertainty_score":0.6372605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311180398526197,"score_gpt":0.2997366033922694,"score_spread":0.2766247994070074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}