{"id":"W2004822957","doi":"10.2337/dc09-1303","title":"Effect of Direct Renin Inhibition on Renal Hemodynamic Function, Arterial Stiffness, and Endothelial Function in Humans With Uncomplicated Type 1 Diabetes","year":2009,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Toronto General Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University Health Network; University of Toronto; Kidney Foundation of Canada; Canadian Diabetes Association; Amgen Canada; Amgen","keywords":"Medicine; Internal medicine; Endocrinology; Pulse wave velocity; Renal function; Aliskiren; Diabetes mellitus; Plasma renin activity; Vasodilation; Hemodynamics; Arterial stiffness; Renin–angiotensin system; Renal blood flow; Type 2 diabetes; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004389526,0.0003651478,0.0006487914,0.0001782251,0.000205064,0.0003667444,0.0001187351,0.0002727328,0.0005916695],"category_scores_gemma":[0.001073943,0.0001512421,0.0002122402,0.0001762369,0.0002989396,0.0001421415,0.0001853701,0.0005930527,0.00006928933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970149,"about_ca_system_score_gemma":0.0001668884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007540722,"about_ca_topic_score_gemma":0.001316392,"domain_scores_codex":[0.9997914,0.00007914877,0.0000208101,0.00003402105,0.0000490822,0.00002542195],"domain_scores_gemma":[0.9994556,0.0001588638,0.0001725121,0.00004242062,0.00002041534,0.0001501583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07004169,0.002887587,0.7879643,0.0004442944,0.001190573,0.003087685,0.0004050566,0.0007411644,0.06047186,0.0001424157,0.0004075281,0.07221572],"study_design_scores_gemma":[0.0003983576,0.00807209,0.9870091,0.00001592746,0.0001817462,0.001301458,0.00005758325,0.0003734006,0.002105448,0.00006172275,0.0004129744,0.00001014923],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970354,0.002288973,0.0001052659,0.00004027253,0.00001224763,0.00001256923,0.00004092761,0.000007068106,0.0004573861],"genre_scores_gemma":[0.9989918,0.0006102556,0.0001488391,0.0000663441,0.00002269026,0.000009288401,0.00005759322,0.000001713132,0.00009147481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007540722,"threshold_uncertainty_score":0.002321482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00419067094837396,"score_gpt":0.2176366601758665,"score_spread":0.2134459892274926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}