{"id":"W2004839284","doi":"10.1371/journal.pone.0076481","title":"High-Level Expression, Purification and Characterization of a Constitutively Active Thromboxane A2 Receptor Polymorphic Variant","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institute of General Medical Sciences; National Institutes of Health; Manitoba Medical Service Foundation; Manitoba Health Research Council; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Thromboxane receptor; Receptor; Molecular biology; Chemistry; Biology; Thromboxane A2; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000277142,0.0002721128,0.0003033306,0.0002070432,0.0001555476,0.0005084766,0.0003126134,0.0002982017,0.0004601216],"category_scores_gemma":[0.0002883369,0.0001571765,0.0003285191,0.000413512,0.0001765572,0.0001775297,0.0002441285,0.0007033538,0.0006245953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002720052,"about_ca_system_score_gemma":0.0001610819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007630421,"about_ca_topic_score_gemma":0.0008084232,"domain_scores_codex":[0.9997074,0.00004938179,0.0000415838,0.00005026383,0.0001192707,0.00003203937],"domain_scores_gemma":[0.9998506,0.00002903726,0.00003525686,0.00003377668,0.00002734164,0.00002397788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001196707,0.00001024353,0.00006943306,0.000008361073,0.00000226242,0.00002792939,0.000007226017,0.00003004115,0.9995275,0.00003616545,0.00002273844,0.0002462233],"study_design_scores_gemma":[0.00001321481,0.0001546254,0.003189932,0.000004724197,0.00001600045,0.000821412,0.00003781902,0.001462307,0.9895917,0.00005487971,0.004644513,0.000008926935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834791,0.001016322,0.01200641,0.0002018228,0.00003369649,0.0000656026,0.00220209,0.00008683062,0.0009080833],"genre_scores_gemma":[0.9592838,0.001698512,0.02306429,0.0001186213,0.00003441956,0.0001199046,0.01077772,0.0001167399,0.00478593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007630421,"threshold_uncertainty_score":0.001973569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02833751327731798,"score_gpt":0.2033686793085284,"score_spread":0.1750311660312104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}