{"id":"W2004888680","doi":"10.5339/qfarf.2012.aesnp11","title":"The proprotein convertases in health and disease","year":2012,"lang":"en","type":"article","venue":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Proprotein Convertases; Furin; Proteases; PCSK9; Kexin; Proprotein convertase; Subtilisin; Serine; Biology; Serine protease; Endoplasmic reticulum; Sterol regulatory element-binding protein; Golgi apparatus; Cell biology; Biochemistry; Computational biology; Protease; LDL receptor; Enzyme; Cholesterol; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001514459,0.00009875875,0.0000882273,0.00006713126,0.000386643,0.00006223133,0.0001392179,0.00006333354,0.0001720389],"category_scores_gemma":[0.0003736129,0.00007826586,0.00002892962,0.0001288207,0.000243467,0.00004669469,0.00008389715,0.0001706694,0.0001531093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003625298,"about_ca_system_score_gemma":0.0002393874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003958482,"about_ca_topic_score_gemma":0.0005758546,"domain_scores_codex":[0.9984003,0.0002383453,0.0002088192,0.0002188376,0.0003264311,0.0006072377],"domain_scores_gemma":[0.9990631,0.00002175842,0.00004459151,0.0002730911,0.000134232,0.0004632655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003599238,0.001095565,0.6208861,0.0006990399,0.0001323475,0.00001425113,0.004364121,0.00001565084,0.04582507,0.01625427,0.1388604,0.1682539],"study_design_scores_gemma":[0.0002716283,0.0001823272,0.01466818,0.00001089042,0.000002403795,0.000001596452,0.001145783,0.0001088065,0.0004590981,0.0001737365,0.9828776,0.00009795232],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9118728,0.0366671,0.00531238,0.04165079,0.0005052772,0.003006364,0.0001980096,0.00004022005,0.0007470494],"genre_scores_gemma":[0.9818899,0.001293735,0.00006766901,0.0002683328,0.0002383813,0.00008926119,0.002905963,0.00001948233,0.0132273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8440173,"threshold_uncertainty_score":0.3191589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02521432341481564,"score_gpt":0.3384107680882165,"score_spread":0.3131964446734009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}