{"id":"W2004922200","doi":"10.2217/bmm.10.68","title":"Chromatin Conformation Signatures: Ideal Human Disease Biomarkers?","year":2010,"lang":"en","type":"review","venue":"Biomarkers in Medicine","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chromatin; Chromosome conformation capture; Genome; Human genome; Gene; ChIA-PET; Computational biology; Genetics; Gene expression; DNA; Chromosome; Biology; Ideal (ethics); Evolutionary biology; Chromatin remodeling; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008137464,0.0006462747,0.001133141,0.0003831572,0.0001247995,0.00002473751,0.0006801263,0.0009243758,0.0001041483],"category_scores_gemma":[0.0002873648,0.0005233109,0.0003254854,0.0003099686,0.0003743971,0.000005930668,0.000207393,0.0004617142,0.00001947946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009161478,"about_ca_system_score_gemma":0.0003381915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004700916,"about_ca_topic_score_gemma":0.0001031318,"domain_scores_codex":[0.9972305,0.0001805755,0.001138758,0.0006643885,0.0003264734,0.0004593395],"domain_scores_gemma":[0.998024,0.0000524019,0.0006445815,0.0009121351,0.00007047829,0.0002963718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00013646,0.0002208797,0.0001054634,0.02149896,0.001322008,0.0001200953,0.000127269,0.000003140779,0.01263768,0.0003563136,0.04355873,0.919913],"study_design_scores_gemma":[0.0009335136,0.0001658081,0.0001866625,0.00646056,0.0003506177,0.00002740831,0.00005575215,0.00009264054,0.0000178645,0.00009381185,0.9909943,0.0006210751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001265889,0.994603,0.00008149936,0.00007425401,0.0006108441,0.00105901,0.0001249532,0.0000272272,0.002153369],"genre_scores_gemma":[0.001266827,0.9902794,0.0004567693,0.0001375299,0.0006817653,0.0001328942,0.00678407,0.00009695,0.0001638007],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9474356,"threshold_uncertainty_score":0.9997218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668267372997698,"score_gpt":0.3148815880244911,"score_spread":0.2981989142945141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}