{"id":"W2004922200","doi":"10.2217/bmm.10.68","title":"Chromatin Conformation Signatures: Ideal Human Disease Biomarkers?","year":2010,"lang":"en","type":"review","venue":"Biomarkers in Medicine","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chromatin; Chromosome conformation capture; Genome; Human genome; Gene; ChIA-PET; Computational biology; Genetics; Gene expression; DNA; Chromosome; Biology; Ideal (ethics); Evolutionary biology; Chromatin remodeling; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001518208,0.001227261,0.002342538,0.001825427,0.000256714,0.001437442,0.001302608,0.002410436,0.001644763],"category_scores_gemma":[0.001502859,0.0004363772,0.0003885373,0.001562427,0.001451792,0.002867257,0.0007863842,0.002166639,0.002468036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012597,"about_ca_system_score_gemma":0.0007337784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008734934,"about_ca_topic_score_gemma":0.001093969,"domain_scores_codex":[0.9996459,0.0001032168,0.00003492347,0.00009017123,0.0000991683,0.00002662692],"domain_scores_gemma":[0.9993523,0.0003287329,0.00007342664,0.00003067482,0.0001655277,0.00004947694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001219888,0.0000580807,0.0009127744,0.005805539,0.0001049678,0.0004112241,0.00009873097,0.0005504364,0.005715187,0.01839024,0.03023082,0.9376],"study_design_scores_gemma":[0.00003308491,0.0001126539,0.001523254,0.002589682,0.00009802877,0.003173542,0.0001441582,0.0003984102,0.00308135,0.01624428,0.9725405,0.00006114648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001651054,0.9964859,0.0009387351,0.001117936,0.0002954949,0.000005688392,0.00003163201,0.0000132506,0.0009461284],"genre_scores_gemma":[0.002449841,0.9931931,0.001533277,0.0008945128,0.0004701434,0.00002075714,0.00008183155,0.00000476588,0.001351899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002410436,"threshold_uncertainty_score":0.008029103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668267372997698,"score_gpt":0.3148815880244911,"score_spread":0.2981989142945141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}