{"id":"W2004962670","doi":"10.1074/jbc.m508258200","title":"The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Desmosome; Cadherin; Desmoglein; Cell biology; Desmoglein 1; Keratinocyte; Biology; Apoptosis; Desmoglein 3; Catenin; Cell adhesion; Chemistry; Cell; Cell culture; Signal transduction; Immunology; Biochemistry; Wnt signaling pathway; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007331801,0.0002523809,0.0001280772,0.0002000005,0.0001684753,0.0002318519,0.00009778177,0.0002351583,0.0009249555],"category_scores_gemma":[0.00006781996,0.0000771194,0.0001562634,0.0001296436,0.0001561815,0.000208158,0.0001264266,0.0004157454,0.0002505288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111959,"about_ca_system_score_gemma":0.0001654425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242042,"about_ca_topic_score_gemma":0.0004385206,"domain_scores_codex":[0.9999126,0.00001000834,0.000005474291,0.0000212236,0.00003301867,0.00001764415],"domain_scores_gemma":[0.9999448,0.000005219759,0.0000205075,0.000004602728,0.00001044913,0.00001440474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002403765,0.000006498765,0.000249399,0.00002355463,0.000002090409,0.00005654058,0.000006627366,0.00001850835,0.998421,0.00006891689,0.00001470741,0.001108094],"study_design_scores_gemma":[0.000006754701,0.00008407376,0.01257218,0.000004419263,0.000009179554,0.0006848224,0.000029138,0.0004327934,0.9833459,0.0001241078,0.002703815,0.000002812158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867783,0.005050297,0.005950111,0.0001517387,0.00003035286,0.00003185855,0.0002686647,0.00007704606,0.001661726],"genre_scores_gemma":[0.9941576,0.001626802,0.001764825,0.0000350709,0.000006500512,0.00001285467,0.0002657934,0.000005834735,0.002124848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009249555,"threshold_uncertainty_score":0.003094256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158704925899154,"score_gpt":0.2410470070471547,"score_spread":0.2194599577881631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}