{"id":"W2005028301","doi":"10.1074/jbc.m111.295865","title":"Progesterone Receptor Inhibits Proliferation of Human Breast Cancer Cells via Induction of MAPK Phosphatase 1 (MKP-1/DUSP1)","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Susan G. Komen for the Cure","keywords":"Gene knockdown; Dephosphorylation; Cell growth; Cancer research; MAPK/ERK pathway; Biology; Progesterone receptor; Estrogen receptor; Endocrinology; Internal medicine; Signal transduction; Chemistry; Phosphatase; Cell culture; Molecular biology; Cell biology; Phosphorylation; Cancer; Breast cancer; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046792,0.0003394739,0.0002385665,0.0002189561,0.0001731224,0.0001781673,0.0001148577,0.0001296514,0.001143978],"category_scores_gemma":[0.00008669568,0.0001382857,0.000286874,0.0001967514,0.0001284492,0.00008554092,0.0001731635,0.0003811384,0.000425594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517723,"about_ca_system_score_gemma":0.0003028778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008531884,"about_ca_topic_score_gemma":0.001800958,"domain_scores_codex":[0.9998615,0.00002170774,0.00001329669,0.00002696511,0.00003759276,0.00003892949],"domain_scores_gemma":[0.9999675,0.000004926251,0.000009394867,0.000004397238,0.000005171656,0.00000868792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001226491,0.00003810681,0.0002854739,0.0001006304,0.000007593039,0.00004360841,0.00001774597,0.00004453175,0.9956398,0.00005632579,0.0001620713,0.003481554],"study_design_scores_gemma":[0.00003380444,0.0004801347,0.01204364,0.000006159136,0.00002161702,0.000412294,0.0000315017,0.0006500631,0.9776364,0.00005434167,0.008625767,0.000004365033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780517,0.01492876,0.001978561,0.0003881065,0.00009520243,0.00005806801,0.0009220549,0.000191529,0.003385971],"genre_scores_gemma":[0.9861064,0.006763624,0.001587603,0.00009583864,0.00002115693,0.00007454694,0.001228679,0.00001421656,0.004107834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143978,"threshold_uncertainty_score":0.003827035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615561596188703,"score_gpt":0.2548501040489554,"score_spread":0.2286944880870684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}