{"id":"W2005049504","doi":"10.1007/s00439-005-0078-9","title":"Towards compendia of negative genetic association studies: an example for Alzheimer disease","year":2005,"lang":"en","type":"review","venue":"Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Signe och Olof Wallenius Stiftelse; Fredrik och Ingrid Thurings Stiftelse","keywords":"Biology; Apolipoprotein E; Genetic association; Genetics; Meta-analysis; Human genetics; Genome-wide association study; Population; Disease; Gene; Genotype; Single-nucleotide polymorphism; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03194299,0.001455757,0.004205723,0.004605522,0.0008964924,0.004266982,0.004125373,0.005002064,0.00195392],"category_scores_gemma":[0.04763445,0.0009551407,0.001222121,0.002446884,0.01007587,0.006423168,0.002851826,0.01247841,0.001781127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002409621,"about_ca_system_score_gemma":0.003728051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002479857,"about_ca_topic_score_gemma":0.005275863,"domain_scores_codex":[0.9930543,0.003078902,0.0009826483,0.0005785627,0.002214597,0.00009099472],"domain_scores_gemma":[0.8946693,0.08855157,0.001807274,0.004145045,0.009974884,0.0008519075],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00008959101,0.00008096143,0.0006791572,0.007118405,0.0003455723,0.0005265044,0.0004348322,0.0009099973,0.0011931,0.09552052,0.1421306,0.7509707],"study_design_scores_gemma":[0.00007655308,0.00008583388,0.001002018,0.005874235,0.0002260096,0.002815336,0.0001307313,0.0005874773,0.0005553984,0.1693225,0.8192202,0.0001037917],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002782799,0.9253199,0.03033264,0.0359893,0.004946863,0.00003009817,0.00009867069,0.0002077794,0.002796422],"genre_scores_gemma":[0.004427325,0.891282,0.04742682,0.04248637,0.01093369,0.0001255234,0.0001949834,0.0001258732,0.002997492],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.968057,"threshold_uncertainty_score":0.1689326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2091536642863203,"score_gpt":0.4219349198220738,"score_spread":0.2127812555357535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}