{"id":"W2005052262","doi":"10.1007/s12017-013-8274-6","title":"Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10","year":2013,"lang":"en","type":"article","venue":"NeuroMolecular Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Irish Research Council; Science Foundation Ireland","keywords":"Inflammasome; Cathepsin; Cathepsin B; Cell biology; Caspase 1; Chemistry; Cytosol; Amyloid beta; Amyloid precursor protein; Protein degradation; Cathepsin S; In vivo; Alzheimer's disease; Biochemistry; Biology; Peptide; Enzyme; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408993,0.0003806591,0.0002567872,0.000280889,0.0002124554,0.000475999,0.0001732224,0.0004181796,0.001365036],"category_scores_gemma":[0.0002242157,0.0002085788,0.0005887451,0.0001767595,0.000305533,0.0003653216,0.0003555586,0.0006217349,0.0005655668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005589094,"about_ca_system_score_gemma":0.0003544833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001074735,"about_ca_topic_score_gemma":0.00142547,"domain_scores_codex":[0.9997876,0.00003623867,0.00001606691,0.00002682155,0.00004617716,0.0000870532],"domain_scores_gemma":[0.9998487,0.00002219297,0.00004281822,0.00002532146,0.00002340185,0.00003763062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009442489,0.00005340239,0.0002388074,0.00004415736,0.00001366266,0.0002980141,0.00003081843,0.00003306663,0.9968038,0.0001181584,0.0001167563,0.001305197],"study_design_scores_gemma":[0.0001077018,0.0005868404,0.009021535,0.00001242583,0.00002680198,0.001586029,0.0001362561,0.0007297207,0.9859031,0.0002643274,0.001614379,0.00001081378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931636,0.001741414,0.002413074,0.0002399339,0.00005265519,0.00002199483,0.0001922873,0.00006053441,0.002114544],"genre_scores_gemma":[0.9957425,0.0007234238,0.001119612,0.00008001013,0.00001400116,0.00002172989,0.0002046614,0.0000153257,0.002078681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365036,"threshold_uncertainty_score":0.004566491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00944510187940415,"score_gpt":0.2222311100847542,"score_spread":0.21278600820535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}