{"id":"W2005100675","doi":"10.1016/j.yjmcc.2014.10.014","title":"The immediate effect of HCM causing actin mutants E99K and A230V on actin–Tm–myosin interaction in thin-filament reconstituted myocardium","year":2014,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Australian Historical Association; Heart and Stroke Foundation of Canada","keywords":"Actin; Tropomyosin; Protein filament; Myosin; Biophysics; Cooperativity; Chemistry; Mutant; Troponin; Reaction rate constant; Molecular biology; Kinetics; Biology; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003149979,0.0003710898,0.0003131533,0.0001561964,0.000304624,0.0002801308,0.000499125,0.0005845376,0.002816265],"category_scores_gemma":[0.0003742007,0.0002203098,0.0003407995,0.0001544695,0.0004829729,0.0002726579,0.0002521903,0.00102212,0.0004184846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039588,"about_ca_system_score_gemma":0.0002326116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001657592,"about_ca_topic_score_gemma":0.001200392,"domain_scores_codex":[0.9996178,0.00008773905,0.00004194089,0.00006525923,0.00005978914,0.000127344],"domain_scores_gemma":[0.9996235,0.0001565968,0.00004324641,0.00004945036,0.00003201464,0.00009513435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009956987,0.0001133258,0.0001339931,0.00003164369,0.00001443246,0.000212234,0.00004845727,0.00009703723,0.9976356,0.000199889,0.00008472443,0.0004329965],"study_design_scores_gemma":[0.00005827918,0.0003599915,0.004168466,0.000006474667,0.00001820974,0.0001400914,0.00006653602,0.0012968,0.9933109,0.00005664811,0.0005098569,0.000007699637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974509,0.0003586242,0.0005862533,0.00008597348,0.00005482561,0.00001691145,0.0002298403,0.00002622904,0.001190478],"genre_scores_gemma":[0.9974622,0.0001370981,0.0006747321,0.00006320561,0.00001522053,0.00002345793,0.0002405753,0.00002166025,0.001361862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002816265,"threshold_uncertainty_score":0.009421349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007778957270023886,"score_gpt":0.2505478422714095,"score_spread":0.2427688850013856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}