{"id":"W2005103870","doi":"10.1139/cjpp-2014-0513","title":"Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Biochemical effects in animals","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Carnosic acid; Reactive oxygen species; Superoxide dismutase; Hydrogen peroxide; NAD+ kinase; Antioxidant; Viability assay; Sirtuin 1; Apoptosis; Lactate dehydrogenase; Glutathione; Oxidative stress; Biochemistry; Pharmacology; Enzyme; Downregulation and upregulation; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000440578,0.0001643114,0.0005404184,0.0001449528,0.00005269392,0.000002563753,0.0001906909,0.000240638,0.00008215593],"category_scores_gemma":[0.0002528197,0.0001141363,0.00008805536,0.0002190797,0.0006047036,0.00006612329,0.00003222543,0.0008818881,0.00000469023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639296,"about_ca_system_score_gemma":0.00143364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005957938,"about_ca_topic_score_gemma":0.0002160852,"domain_scores_codex":[0.9985132,0.0005095993,0.0003833722,0.0001812354,0.00008598815,0.0003265941],"domain_scores_gemma":[0.998713,0.0002544041,0.0002924007,0.0001128711,0.0002198834,0.0004074991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008498367,0.00007425217,0.0001234889,0.00004947385,0.0001825193,0.0001042806,0.002714821,0.00001918788,0.9942806,0.00004199894,0.00090486,0.000654712],"study_design_scores_gemma":[0.00245749,0.001706677,0.002180399,0.00006032106,0.00008636803,0.00007318896,0.0003352185,0.00001358743,0.9914913,0.0008477559,0.0006495996,0.00009812473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996974,0.0008044185,0.000002644814,0.001085487,0.0003388049,0.0005000732,0.00001902198,0.000003061855,0.000272488],"genre_scores_gemma":[0.9973698,0.00003381294,0.00005641559,0.00224151,0.000260237,0.00001390414,0.000002826131,0.00001371482,0.000007735362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002789299,"threshold_uncertainty_score":0.4654343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851677248431459,"score_gpt":0.3031689403272305,"score_spread":0.2746521678429159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}