{"id":"W2005103870","doi":"10.1139/cjpp-2014-0513","title":"Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Biochemical effects in animals","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Carnosic acid; Reactive oxygen species; Superoxide dismutase; Hydrogen peroxide; NAD+ kinase; Antioxidant; Viability assay; Sirtuin 1; Apoptosis; Lactate dehydrogenase; Glutathione; Oxidative stress; Biochemistry; Pharmacology; Enzyme; Downregulation and upregulation; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395879,0.0003632658,0.0004219142,0.0002003696,0.0002049461,0.0002193923,0.0001545829,0.000242892,0.0009425146],"category_scores_gemma":[0.00008356399,0.0001235783,0.000386593,0.0001626381,0.0001850411,0.0002032409,0.0001720132,0.0003911035,0.0001985038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372056,"about_ca_system_score_gemma":0.0002859355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001327541,"about_ca_topic_score_gemma":0.001887385,"domain_scores_codex":[0.9999365,0.00001565497,0.000007977613,0.00001361583,0.000009509496,0.0000167039],"domain_scores_gemma":[0.9999529,0.000003876491,0.0000134389,0.00000738593,0.00001039561,0.00001195946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001013613,0.00006044016,0.0005106523,0.000238266,0.00003473224,0.0001244487,0.00004751787,0.00009428442,0.9949897,0.0001004907,0.0001623208,0.002623461],"study_design_scores_gemma":[0.0001387083,0.001295848,0.007379018,0.00002251815,0.0001260546,0.0003466945,0.0000980332,0.0008404979,0.9834344,0.00008754899,0.00621522,0.00001544895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984259,0.01142147,0.001659607,0.0003011295,0.0001069667,0.00003280714,0.0004554414,0.0001193414,0.001644135],"genre_scores_gemma":[0.9941862,0.00261142,0.001157353,0.000121066,0.00001927281,0.00002657302,0.000502884,0.00001080672,0.001364414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327541,"threshold_uncertainty_score":0.003153086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851677248431459,"score_gpt":0.3031689403272305,"score_spread":0.2746521678429159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}