{"id":"W2005104380","doi":"10.1016/j.msard.2014.05.005","title":"First-dose effects of fingolimod: Pooled safety data from three phase 3 studies","year":2014,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novartis Pharma; National Research Foundation; Novartis","keywords":"Fingolimod; Medicine; Bradycardia; Cardiology; Heart rate; Internal medicine; Electrocardiography; Atrioventricular block; Anesthesia; Disopyramide; Multiple sclerosis; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009010822,0.001964728,0.005833055,0.001192841,0.000476056,0.002237316,0.0009502786,0.001527278,0.002630488],"category_scores_gemma":[0.008257388,0.0006787679,0.00997171,0.001280219,0.0006136672,0.001411382,0.0006692899,0.00223561,0.0005064341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001161844,"about_ca_system_score_gemma":0.001181413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007140161,"about_ca_topic_score_gemma":0.001381279,"domain_scores_codex":[0.9966308,0.001559125,0.0004363428,0.0005257354,0.0005540061,0.0002939292],"domain_scores_gemma":[0.9934783,0.002655537,0.00206181,0.0009091146,0.0005213954,0.0003739113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.5973316,0.001920351,0.02563029,0.008944248,0.1774797,0.0003604699,0.0002512146,0.005710708,0.01793334,0.000290998,0.005379474,0.1587675],"study_design_scores_gemma":[0.28704,0.1118211,0.2429496,0.001271655,0.3191112,0.001890646,0.0002604699,0.003170101,0.01389623,0.00237282,0.0159073,0.0003089216],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7986938,0.169647,0.00905196,0.000810054,0.0005041753,0.002623912,0.01046728,0.0007434345,0.007458454],"genre_scores_gemma":[0.9716115,0.01659425,0.002020531,0.0009453366,0.0003580779,0.0008356075,0.0063774,0.0001250855,0.001132189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009010822,"threshold_uncertainty_score":0.04765433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02777977866621691,"score_gpt":0.257610424226585,"score_spread":0.2298306455603681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}