{"id":"W2005112733","doi":"10.3109/02713683.2013.779720","title":"Direct Comparison of Administration Routes for AAV8-mediated Ocular Gene Therapy","year":2013,"lang":"en","type":"article","venue":"Current Eye Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; University of Pennsylvania","keywords":"Genetic enhancement; Green fluorescent protein; Retinal pigment epithelium; Transduction (biophysics); Gene delivery; Electroretinography; In vivo; Retina; Retinal; Molecular biology; Viral vector; Systemic administration; Biology; Intravitreal administration; Photoreceptor cell; Gene expression; Luciferase; Pathology; Medicine; Cell biology; Transfection; Ophthalmology; Cell culture; Gene; Recombinant DNA; Biophysics; Biochemistry; Neuroscience; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003822537,0.00009658826,0.0001392272,0.00006928325,0.00008282081,0.0000338738,0.0001840403,0.00008144359,0.0000501741],"category_scores_gemma":[0.0002317327,0.00008240372,0.00007285175,0.0001357802,0.00009947132,0.000005339192,0.00005009835,0.0000842034,0.0000274931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009671957,"about_ca_system_score_gemma":0.0001463592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001298932,"about_ca_topic_score_gemma":0.000005245422,"domain_scores_codex":[0.9988943,0.0000958278,0.0002183854,0.0002401615,0.0002752424,0.0002760316],"domain_scores_gemma":[0.9992142,0.00005531427,0.00005519193,0.0001903952,0.0004106952,0.00007419188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091916,0.00036438,0.05577671,0.00007582162,0.00005007575,1.325955e-7,0.00009960062,0.000004169031,0.8939,0.00004793527,0.01646455,0.03300743],"study_design_scores_gemma":[0.0007602512,0.0007054356,0.02420954,0.0000198499,0.000003266277,1.653447e-7,0.0001273959,0.0003072749,0.8774204,0.00012411,0.09617331,0.0001489747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896911,0.007979897,0.0005922239,0.0001653282,0.0001079336,0.0007333399,0.00001551765,0.000007465538,0.0007072133],"genre_scores_gemma":[0.9966789,0.00171519,0.0002933503,0.000006955236,0.00008935454,0.000211224,0.0007347785,0.00001302235,0.0002571508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07970876,"threshold_uncertainty_score":0.3360326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008579870615907,"score_gpt":0.4385461792531822,"score_spread":0.3376881921915915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}