{"id":"W2005112733","doi":"10.3109/02713683.2013.779720","title":"Direct Comparison of Administration Routes for AAV8-mediated Ocular Gene Therapy","year":2013,"lang":"en","type":"article","venue":"Current Eye Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; University of Pennsylvania","keywords":"Genetic enhancement; Green fluorescent protein; Retinal pigment epithelium; Transduction (biophysics); Gene delivery; Electroretinography; In vivo; Retina; Retinal; Molecular biology; Viral vector; Systemic administration; Biology; Intravitreal administration; Photoreceptor cell; Gene expression; Luciferase; Pathology; Medicine; Cell biology; Transfection; Ophthalmology; Cell culture; Gene; Recombinant DNA; Biophysics; Biochemistry; Neuroscience; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006758725,0.0004900904,0.0003834766,0.0006685329,0.0001692111,0.0007799612,0.0003345882,0.0005415611,0.001693642],"category_scores_gemma":[0.0007919593,0.0001791282,0.0004526883,0.0002511078,0.0002970112,0.0009121586,0.000292562,0.0007489274,0.0007583452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004093235,"about_ca_system_score_gemma":0.0003748422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008679939,"about_ca_topic_score_gemma":0.001025115,"domain_scores_codex":[0.9992334,0.000134004,0.00008880519,0.0001970214,0.000256944,0.0000898693],"domain_scores_gemma":[0.9993292,0.000182043,0.0002098221,0.00007239788,0.0001551376,0.00005153503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005607912,0.0002550476,0.001106416,0.0003034869,0.0000337653,0.00006353749,0.00006900923,0.0001792401,0.9777605,0.0002878817,0.000180587,0.01919972],"study_design_scores_gemma":[0.00007528711,0.004977852,0.006450383,0.00005807426,0.0002216404,0.0007409579,0.0001109397,0.001739248,0.9759933,0.0001649747,0.009441391,0.00002603322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362591,0.0212319,0.0355284,0.0002716958,0.0003563038,0.0005315798,0.0007971554,0.0003829128,0.004641043],"genre_scores_gemma":[0.9487109,0.01293149,0.0312563,0.0001035303,0.00009710003,0.0005061938,0.001116458,0.0001783351,0.005099579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001693642,"threshold_uncertainty_score":0.005665779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1008579870615907,"score_gpt":0.4385461792531822,"score_spread":0.3376881921915915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}