{"id":"W2005113813","doi":"10.1016/j.bmc.2012.05.042","title":"Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Hyoscyamine; Atropa belladonna; Tropane; Chemistry; Datura; Scopolamine; Stereochemistry; Biochemistry; Solanaceae; Biology; Botany; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005345313,0.0002871015,0.0003798853,0.00004635226,0.0001311837,0.000005783731,0.0002561716,0.0003408519,0.01152467],"category_scores_gemma":[0.00009529295,0.0002685186,0.0001092522,0.0002256141,0.0002071581,0.00009754929,0.0001148555,0.0005543509,0.0001695963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006733665,"about_ca_system_score_gemma":0.0001182701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002099443,"about_ca_topic_score_gemma":3.414692e-7,"domain_scores_codex":[0.9981946,0.0001285012,0.0005368099,0.0003058048,0.0003258311,0.0005084262],"domain_scores_gemma":[0.9987083,0.0001397893,0.0003165972,0.0002193216,0.0001179468,0.0004980214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002571985,0.0005489485,0.006092211,0.00008328654,0.0001531434,0.000009239354,0.0002334409,0.000001467193,0.9847382,0.00002253703,0.001732499,0.006127877],"study_design_scores_gemma":[0.001853612,0.00002505464,0.02788491,0.00002096019,0.000450346,0.00003561147,0.00005379866,0.0001456779,0.8819247,0.00005139725,0.08731694,0.0002369946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907088,0.003562937,0.0002472508,0.0005270646,0.003437154,0.0001620068,0.0001849329,0.00005635364,0.0011135],"genre_scores_gemma":[0.9931524,0.001062137,0.00006165427,0.0007502369,0.002838517,0.00001637674,0.0005939928,0.0000382994,0.001486367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1028135,"threshold_uncertainty_score":0.9999767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08144738520202573,"score_gpt":0.3575645116783777,"score_spread":0.276117126476352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}