{"id":"W2005130814","doi":"10.1210/en.2004-1637","title":"The Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide Is Hydrolyzed and Its Signaling Properties Are Altered by Directly Binding the Calpain Small Subunit","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Calpain; Parathyroid hormone; Parathyroid hormone receptor; Receptor; Calpastatin; HEK 293 cells; Molecular biology; Chemistry; Biology; Internal medicine; Endocrinology; Cell biology; Biochemistry; Calcium; Hormone receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002791727,0.000224642,0.0001901184,0.00003956035,0.0006303124,0.00006648635,0.0001416319,0.0001647053,0.000005197962],"category_scores_gemma":[0.0001547375,0.0001411566,0.00007428455,0.00007310423,0.0002091766,0.000009901109,0.00009904896,0.0001748447,0.000009649561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001977971,"about_ca_system_score_gemma":0.00002735003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001338747,"about_ca_topic_score_gemma":0.0000341546,"domain_scores_codex":[0.9985678,0.0002081705,0.0003047344,0.0004108328,0.00008239238,0.0004260531],"domain_scores_gemma":[0.9993545,0.00009390328,0.0001646372,0.0002256987,0.00007926789,0.00008200025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004261599,0.00002478209,0.00004952354,0.000005901064,0.000105397,6.119462e-7,0.0002128093,0.00003123851,0.9794726,0.00007053687,0.0169269,0.002673561],"study_design_scores_gemma":[0.001985979,0.0004712277,0.0005095571,0.00000927873,0.00005275128,0.00007369603,0.0004628071,0.002334743,0.6823426,0.00005264783,0.3114071,0.0002975129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.934526,0.05980274,0.0001913184,0.004579316,0.00007109705,0.0007078768,0.00003780212,0.00003412899,0.00004977753],"genre_scores_gemma":[0.9892434,0.004454379,0.00008313812,0.0003845969,0.0002482273,0.000237657,0.00008992136,0.00003080848,0.005227807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2971299,"threshold_uncertainty_score":0.5756198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493517996714032,"score_gpt":0.2197646769422406,"score_spread":0.2048294969751003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}