{"id":"W2005130814","doi":"10.1210/en.2004-1637","title":"The Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide Is Hydrolyzed and Its Signaling Properties Are Altered by Directly Binding the Calpain Small Subunit","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Calpain; Parathyroid hormone; Parathyroid hormone receptor; Receptor; Calpastatin; HEK 293 cells; Molecular biology; Chemistry; Biology; Internal medicine; Endocrinology; Cell biology; Biochemistry; Calcium; Hormone receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001418765,0.0004410389,0.000231044,0.0001541503,0.0001320713,0.0002874167,0.0002920447,0.0003560407,0.002739158],"category_scores_gemma":[0.0001819883,0.0001946046,0.0004086434,0.0001331319,0.0002139298,0.0002261774,0.000180459,0.000638132,0.0008726851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002808149,"about_ca_system_score_gemma":0.0001667838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004089138,"about_ca_topic_score_gemma":0.0004497555,"domain_scores_codex":[0.9998211,0.00002111748,0.00001404547,0.0000440195,0.0000629491,0.00003673144],"domain_scores_gemma":[0.9998925,0.00002313582,0.00003591153,0.00001670242,0.000008794651,0.00002301049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003480517,0.000007672919,0.00006492132,0.00001293715,0.000002857042,0.0000357444,0.000003043159,0.000007760219,0.9991589,0.00002562692,0.00001998641,0.0006258293],"study_design_scores_gemma":[0.00002036159,0.0001606981,0.006777754,0.000003261451,0.0000144068,0.0008937668,0.00001262095,0.0003599962,0.9884483,0.00004604011,0.00325859,0.000004225327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908579,0.003056693,0.003577941,0.0002798249,0.00005436297,0.00002312714,0.000541892,0.0001032974,0.001504946],"genre_scores_gemma":[0.9865813,0.002116342,0.003420113,0.0001295067,0.00002516733,0.00004940728,0.001936225,0.00003116601,0.005710743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002739158,"threshold_uncertainty_score":0.00916338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493517996714032,"score_gpt":0.2197646769422406,"score_spread":0.2048294969751003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}