{"id":"W2005138291","doi":"10.1124/jpet.113.208256","title":"Impact of Nicotine Metabolism on Nicotine’s Pharmacological Effects and Behavioral Responses: Insights from a Cyp2a(4/5)bgs-Null Mouse","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Toronto","keywords":"Nicotine; Conditioned place preference; Pharmacology; Endocrinology; Chemistry; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005276225,0.001386212,0.0007980429,0.001585585,0.0005934915,0.0008736702,0.0008318939,0.00140813,0.004460005],"category_scores_gemma":[0.0003609312,0.0006636743,0.001168055,0.0003911607,0.001451409,0.0008386603,0.000550381,0.002986352,0.0007377519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000827887,"about_ca_system_score_gemma":0.000620427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094632,"about_ca_topic_score_gemma":0.004387285,"domain_scores_codex":[0.9992901,0.00007830645,0.00008876788,0.0001952982,0.0002184549,0.0001290388],"domain_scores_gemma":[0.9992441,0.000117634,0.0002091157,0.00009470292,0.00005914511,0.0002752179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007770412,0.0001785816,0.0004605187,0.00002160402,0.00002099308,0.0001913845,0.00003120755,0.00007195532,0.9967817,0.000230946,0.00008359391,0.001150403],"study_design_scores_gemma":[0.0001340625,0.0008864866,0.007832604,0.00001635068,0.0001956586,0.0007442599,0.0001482342,0.001424285,0.9861085,0.00031445,0.00216644,0.00002869851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886655,0.0006930702,0.006129479,0.0008283394,0.0001562915,0.00006244551,0.001777755,0.0002383023,0.001448875],"genre_scores_gemma":[0.9757965,0.0009635191,0.007215596,0.0004732304,0.00007512756,0.000167261,0.001558601,0.0004179248,0.01333221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004460005,"threshold_uncertainty_score":0.01492023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033147349602456,"score_gpt":0.3680153693600367,"score_spread":0.3476838958640122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}