{"id":"W2005153574","doi":"10.1002/hep.24391","title":"Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis","year":2011,"lang":"en","type":"article","venue":"Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"GLUT2; Endocrinology; Internal medicine; Cholesterol 7 alpha-hydroxylase; Gluconeogenesis; Organic anion transporter 1; Biology; Glucokinase; Bile acid; Lipid metabolism; Transporter; Metabolism; Glucose transporter; Biochemistry; Medicine; Insulin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001756702,0.0003180669,0.0006699917,0.0001751239,0.00009752447,0.00001090717,0.00008735669,0.0002381217,0.0002379813],"category_scores_gemma":[0.00001141183,0.0002636037,0.00009402826,0.0001486813,0.000216483,0.0001401989,0.00001313779,0.0002441151,0.00001582873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002386322,"about_ca_system_score_gemma":0.00004269936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001189824,"about_ca_topic_score_gemma":0.0008447502,"domain_scores_codex":[0.9982977,0.00004063852,0.000561627,0.0005078914,0.0001456198,0.0004465154],"domain_scores_gemma":[0.9992376,0.00002758199,0.0001415686,0.0002759177,0.00005229134,0.0002650459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001195701,0.0002354517,0.5940059,0.0003693894,0.0001443569,0.000477912,0.005323139,9.126277e-9,0.3692958,0.0001062518,0.00003605826,0.02880995],"study_design_scores_gemma":[0.007132091,0.002841513,0.7328765,0.000437452,0.001038274,0.001730513,0.001208372,0.0001683954,0.2494272,0.0004170011,0.001773037,0.0009497071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933754,0.004422163,0.00100282,0.0002951201,0.0001721758,0.0003877665,0.00002249308,0.0001229889,0.0001990453],"genre_scores_gemma":[0.9937612,0.003636973,0.001801712,0.0004865934,0.00005403002,0.00002764834,0.0000542497,0.00006010647,0.0001174689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1388705,"threshold_uncertainty_score":0.9999816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496186269847405,"score_gpt":0.2344892783747806,"score_spread":0.2195274156763065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}