{"id":"W2005153574","doi":"10.1002/hep.24391","title":"Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis","year":2011,"lang":"en","type":"article","venue":"Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"GLUT2; Endocrinology; Internal medicine; Cholesterol 7 alpha-hydroxylase; Gluconeogenesis; Organic anion transporter 1; Biology; Glucokinase; Bile acid; Lipid metabolism; Transporter; Metabolism; Glucose transporter; Biochemistry; Medicine; Insulin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467725,0.0002459686,0.0002628361,0.0001446898,0.00011421,0.0003697994,0.0001583587,0.0003555086,0.00140906],"category_scores_gemma":[0.0001283182,0.0001002627,0.0001747603,0.0001937872,0.0003741019,0.000184727,0.0001786072,0.0002660073,0.0002948733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166527,"about_ca_system_score_gemma":0.0001883959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008632072,"about_ca_topic_score_gemma":0.001088304,"domain_scores_codex":[0.9998859,0.00001897999,0.000007781859,0.00003323461,0.00002211435,0.0000319465],"domain_scores_gemma":[0.9999114,0.0000125873,0.00003197649,0.000008921925,0.00001057314,0.00002452815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001446531,0.0000372326,0.01281905,0.0001506545,0.00003336509,0.0003081607,0.00004072684,0.00008401881,0.9785005,0.0001841679,0.000113656,0.006281944],"study_design_scores_gemma":[0.0001268921,0.001215237,0.2778067,0.00005544775,0.000418211,0.003222745,0.0004719105,0.001575187,0.7028384,0.0005257691,0.01171454,0.00002901941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871345,0.009100371,0.001830296,0.0002742837,0.00003581931,0.00001669181,0.0003244149,0.00004659283,0.001236976],"genre_scores_gemma":[0.9961844,0.001889018,0.000648414,0.00006117002,0.0000193678,0.00001482221,0.0002241494,0.00001131999,0.0009473538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00140906,"threshold_uncertainty_score":0.004713774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496186269847405,"score_gpt":0.2344892783747806,"score_spread":0.2195274156763065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}