{"id":"W2005176113","doi":"10.1158/0008-5472.can-14-2789","title":"Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development","year":2015,"lang":"en","type":"review","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":370,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"PI3K/AKT/mTOR pathway; Biology; Carcinogenesis; Cancer; Cell biology; Translation (biology); Cancer cell; Angiogenesis; Protein kinase B; Cancer research; Signal transduction; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266905,0.0003125116,0.0005657975,0.0001159289,0.0004070302,0.0001072087,0.0006133677,0.0004102678,0.0001167165],"category_scores_gemma":[0.0004688424,0.0002344309,0.0001945573,0.0002663988,0.0002563338,0.000007579155,0.0001405262,0.0005338307,0.00001349167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000560784,"about_ca_system_score_gemma":0.004291954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001148828,"about_ca_topic_score_gemma":0.0002169771,"domain_scores_codex":[0.9969583,0.0004978151,0.0005378214,0.0006587313,0.0006578739,0.0006894792],"domain_scores_gemma":[0.9977361,0.0003288612,0.0001355362,0.0003909954,0.001257252,0.0001512838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008595841,0.00003466035,0.000003254117,0.006101538,0.0002285532,0.000001738051,0.0002578816,0.00008588452,0.002571276,0.00007301015,0.04170748,0.9488488],"study_design_scores_gemma":[0.0002514698,0.00008767027,9.437115e-7,0.001541834,0.0001039763,0.000002812173,0.00004261328,0.00006099778,0.0007667009,0.00007994679,0.9967679,0.000293081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003955797,0.994635,0.002158663,0.0003343002,0.0005353291,0.001595091,0.0004115951,0.00001584273,0.0002745808],"genre_scores_gemma":[0.0004387758,0.9877273,0.0009228422,0.0001148981,0.00238485,0.006640433,0.001396412,0.000112413,0.0002620428],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9550605,"threshold_uncertainty_score":0.9559816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4698480076737247,"score_gpt":0.554754726209358,"score_spread":0.08490671853563325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}